Expression of ATRAID in cancer - Summary

CANCER ATLAS

Gene description

All-trans retinoic acid-induced differentiation factor

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Renal cancer

STAINING SUMMARY

HPA051353

GENE INFORMATION
Gene name	ATRAID (HGNC Symbol)
Synonyms	APR3, C2orf28, HSPC013, p18
Description	All-trans retinoic acid-induced differentiation factor (HGNC Symbol)
Entrez gene summary	This gene is thought to be involved in apoptosis, and may also be involved in hematopoietic development and differentiation. The use of alternative splice sites and promotors result in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2009]
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	27212027 - 27217178
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138085 (version 83.38)
Entrez gene	51374
UniProt	Q6UW56 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UW56
Antibodypedia	ATRAID antibodies

PROTEIN BROWSER

ATRAID-001	ATRAID-002	ATRAID-003	ATRAID-007	ATRAID-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATRAID-001 ENSP00000369518 ENST00000380171	Q6UW56 [Direct mapping] All-trans retinoic acid-induced differentiation factor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005886 [plasma membrane] GO:0010468 [regulation of gene expression] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0030501 [positive regulation of bone mineralization] GO:0033689 [negative regulation of osteoblast proliferation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0048471 [perinuclear region of cytoplasm] GO:2000599 [negative regulation of cyclin catabolic process] Show all	284 aa 30.3 kDa	No	2
ATRAID-002 ENSP00000384033 ENST00000405489	Q6UW56 [Direct mapping] All-trans retinoic acid-induced differentiation factor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005886 [plasma membrane] GO:0010468 [regulation of gene expression] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0030501 [positive regulation of bone mineralization] GO:0033689 [negative regulation of osteoblast proliferation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0048471 [perinuclear region of cytoplasm] GO:2000599 [negative regulation of cyclin catabolic process] Show all	171 aa 18.6 kDa	No	1
ATRAID-003 ENSP00000397319 ENST00000419744	C9JA62 [Direct mapping] All-trans retinoic acid-induced differentiation factor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		75 aa 8.2 kDa	No	0
ATRAID-007 ENSP00000476080 ENST00000606999	Q6UW56 [Direct mapping] All-trans retinoic acid-induced differentiation factor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005886 [plasma membrane] GO:0010468 [regulation of gene expression] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0030501 [positive regulation of bone mineralization] GO:0033689 [negative regulation of osteoblast proliferation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0048471 [perinuclear region of cytoplasm] GO:2000599 [negative regulation of cyclin catabolic process] Show all	229 aa 24.7 kDa	Yes	1
ATRAID-201 ENSP00000484228 ENST00000611786	Q6UW56 [Direct mapping] All-trans retinoic acid-induced differentiation factor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0010468 [regulation of gene expression] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0030501 [positive regulation of bone mineralization] GO:0033689 [negative regulation of osteoblast proliferation] GO:0045669 [positive regulation of osteoblast differentiation] GO:0048471 [perinuclear region of cytoplasm] GO:2000599 [negative regulation of cyclin catabolic process] Show all	284 aa 30.3 kDa	No	2