Expression of ACTR1A in cancer - Summary

CANCER ATLAS

Gene description

ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB037193

GENE INFORMATION
Gene name	ACTR1A (HGNC Symbol)
Synonyms	ARP1, Arp1A
Description	ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) (HGNC Symbol)
Entrez gene summary	This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q24.32
Chromosome location (bp)	102479229 - 102502711
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138107 (version 83.38)
Entrez gene	10121
UniProt	P61163 (UniProt - Evidence at protein level)
neXtProt	NX_P61163
Antibodypedia	ACTR1A antibodies

PROTEIN BROWSER

ACTR1A-001	ACTR1A-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACTR1A-001 ENSP00000358921 ENST00000369905	P61163 [Direct mapping] Alpha-centractin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005869 [dynactin complex] GO:0005875 [microtubule associated complex] GO:0006996 [organelle organization] GO:0016192 [vesicle-mediated transport] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0043209 [myelin sheath] GO:0070062 [extracellular exosome] Show all	376 aa 42.6 kDa	No	0
ACTR1A-002 ENSP00000473334 ENST00000487599	R4GMT0 [Direct mapping] Alpha-centractin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005869 [dynactin complex] Show all	332 aa 37.4 kDa	No	0