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ACTR1A

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GENERAL INFORMATION

Gene name

 ACTR1A

Gene description

 ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the microtubules. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Microtubules (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA047443
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the microtubules. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Microtubules (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA047443 A-431 Microtubules
HPA047443 U-2 OS Microtubules
HPA047443 U-251 MG Microtubules

GENE INFORMATION

Gene name

 ACTR1A (HGNC Symbol)

Synonyms

 ARP1, Arp1A

Description

 ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) (HGNC Symbol)

Entrez gene summary

 This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q24.32

Chromosome location (bp)

 102479229 - 102502711

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138107 (version 83.38)

Entrez gene

 10121

UniProt

 P61163 (UniProt - Evidence at protein level)

neXtProt

 NX_P61163

Antibodypedia

 ACTR1A antibodies

PROTEIN BROWSER
ACTR1A-001
ACTR1A-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACTR1A-001
ENSP00000358921
ENST00000369905
P61163 [Direct mapping]
Alpha-centractin
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005869 [dynactin complex]
GO:0005875 [microtubule associated complex]
GO:0006996 [organelle organization]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0043209 [myelin sheath]
GO:0070062 [extracellular exosome]
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 376 aa
42.6 kDa 		No 0
ACTR1A-002
ENSP00000473334
ENST00000487599
R4GMT0 [Direct mapping]
Alpha-centractin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005869 [dynactin complex]
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 332 aa
37.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.