Expression of ENTPD1 in cancer - Summary

CANCER ATLAS

Gene description

Ectonucleoside triphosphate diphosphohydrolase 1

Protein class

CD markers, Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA014067	CAB002494

GENE INFORMATION
Gene name	ENTPD1 (HGNC Symbol)
Synonyms	ATPDase, CD39, NTPDase-1, SPG64
Description	Ectonucleoside triphosphate diphosphohydrolase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Chromosome	10
Cytoband	q24.1
Chromosome location (bp)	95711779 - 95869695
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138185 (version 83.38)
Entrez gene	953
UniProt	P49961 (UniProt - Evidence at protein level)
neXtProt	NX_P49961
Antibodypedia	ENTPD1 antibodies

PROTEIN BROWSER

ENTPD1-005	ENTPD1-008	ENTPD1-012	ENTPD1-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ENTPD1-005 ENSP00000390955 ENST00000453258	P49961 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 1 Show all	Enzymes ENZYME proteins Hydrolases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	517 aa 58.7 kDa	No	1
ENTPD1-008 ENSP00000360248 ENST00000371205	P49961 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 1 Show all	Enzymes ENZYME proteins Hydrolases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	510 aa 58 kDa	No	1
ENTPD1-012 ENSP00000442968 ENST00000543964	P49961 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 1 Show all	Enzymes ENZYME proteins Hydrolases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	402 aa 46.2 kDa	No	1
ENTPD1-015 ENSP00000360250 ENST00000371207	P49961 [Direct mapping] Ectonucleoside triphosphate diphosphohydrolase 1 Show all	Enzymes ENZYME proteins Hydrolases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007596 [blood coagulation] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0070062 [extracellular exosome] Show all	522 aa 59.3 kDa	No	1