Cell atlas - EXOC6 - The Human Protein Atlas

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EXOC6

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	EXOC6
Gene description	Exocyst complex component 6
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the nucleoplasm.
RNA cell category	Cell line enhanced (HUVEC TERT2)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA059111
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HUVEC TERT2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the nucleoplasm.

Main location

Vesicles (supported)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059111	A-431	Nucleoplasm
	HPA059111	A-431	Vesicles
	HPA059111	A549	Nucleoplasm
	HPA059111	A549	Vesicles
	HPA059111	U-2 OS	Nucleoplasm
	HPA059111	U-2 OS	Vesicles

GENE INFORMATION
Gene name	EXOC6 (HGNC Symbol)
Synonyms	DKFZp761I2124, EXOC6A, FLJ1125, MGC33397, SEC15L, SEC15L1, Sec15p
Description	Exocyst complex component 6 (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the SEC15 family. It is highly similar to the protein encoded by Saccharomyces cerevisiae SEC15 gene. This protein is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q23.33
Chromosome location (bp)	92834713 - 93059493
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138190 (version 83.38)
Entrez gene	54536
UniProt	Q8TAG9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TAG9
Antibodypedia	EXOC6 antibodies

PROTEIN BROWSER

EXOC6-001	EXOC6-003	EXOC6-004	EXOC6-201	EXOC6-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EXOC6-001 ENSP00000260762 ENST00000260762	Q8TAG9 [Direct mapping] Exocyst complex component 6 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006904 [vesicle docking involved in exocytosis] GO:0006996 [organelle organization] GO:0015031 [protein transport] GO:0030218 [erythrocyte differentiation] GO:0044267 [cellular protein metabolic process] GO:0061024 [membrane organization] Show all	804 aa 93.7 kDa	No	0
EXOC6-003 ENSP00000360598 ENST00000371543	B1AP46 [Direct mapping] Exocyst complex component 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0006904 [vesicle docking involved in exocytosis] Show all	153 aa 17.7 kDa	No	0
EXOC6-004 ENSP00000398982 ENST00000458552	H0Y5J8 [Direct mapping] Exocyst complex component 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0006904 [vesicle docking involved in exocytosis] Show all	72 aa 7.9 kDa	No	0
EXOC6-201 ENSP00000360607 ENST00000371552	Q8TAG9 [Direct mapping] Exocyst complex component 6 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006904 [vesicle docking involved in exocytosis] GO:0006996 [organelle organization] GO:0015031 [protein transport] GO:0044267 [cellular protein metabolic process] GO:0061024 [membrane organization] Show all	799 aa 93.4 kDa	No	0
EXOC6-202 ENSP00000396206 ENST00000443748	E7EW84 [Direct mapping] Exocyst complex component 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0006904 [vesicle docking involved in exocytosis] Show all	701 aa 81.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.