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Most cancer tissues showed weak to moderate cytoplasmic and nuclear staining. Several cases of prostate cancers displayed strong positivity while few cases of endometrial cancers exhibited strong cytoplasmic immunoreactivity. Lymphomas, melanomas, thyroid and skin cancers were negative.
Most cancer tissues showed weak to moderate cytoplasmic and nuclear immunoreactivity. Gliomas, lymphomas, melanomas, squamous cell and basal cell carcinomas along with renal, pancreatic and liver cancers were mostly negative.
Majority of tumor tissues displayed weak to moderate cytoplasmic and nuclear positivity. Membranous staining was observed in few cases of colorectal, pancreatic and endometrial cancers. Prostate cancers along with occasional cases of breast, endometrial, stomach and pancreatic cancers were strongly stained. Most of the cases of lymphomas, melanomas, skin and renal cancers were negative.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding] GO:0004448 [isocitrate dehydrogenase activity] GO:0004450 [isocitrate dehydrogenase (NADP+) activity] GO:0005102 [receptor binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0005829 [cytosol] GO:0006097 [glyoxylate cycle] GO:0006099 [tricarboxylic acid cycle] GO:0006102 [isocitrate metabolic process] GO:0006103 [2-oxoglutarate metabolic process] GO:0006740 [NADPH regeneration] GO:0006749 [glutathione metabolic process] GO:0006979 [response to oxidative stress] GO:0008585 [female gonad development] GO:0014070 [response to organic cyclic compound] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0042803 [protein homodimerization activity] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0048545 [response to steroid hormone] GO:0050661 [NADP binding] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] GO:0060696 [regulation of phospholipid catabolic process] GO:0070062 [extracellular exosome] GO:0071071 [regulation of phospholipid biosynthetic process]
Predicted intracellular proteins Citric acid cycle related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
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GO:0004450 [isocitrate dehydrogenase (NADP+) activity] GO:0006102 [isocitrate metabolic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0055114 [oxidation-reduction process]
Predicted intracellular proteins Citric acid cycle related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
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GO:0004450 [isocitrate dehydrogenase (NADP+) activity] GO:0006102 [isocitrate metabolic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0055114 [oxidation-reduction process]
Predicted intracellular proteins Citric acid cycle related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)
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GO:0004450 [isocitrate dehydrogenase (NADP+) activity] GO:0006102 [isocitrate metabolic process] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0055114 [oxidation-reduction process]
