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IDH1

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GENERAL INFORMATION

Gene name

 IDH1

Gene description

 Isocitrate dehydrogenase 1 (NADP+), soluble

Protein class

 Cancer-related genes
Citric acid cycle related proteins
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & nuclear bodies.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear bodies (approved), Cytosol (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
CAB062556
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & nuclear bodies.

Main location

 Nuclear bodies (approved), Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB062556 A-431 Nuclear bodies
Cytosol
CAB062556 BJ Cytosol
CAB062556 U-2 OS Nuclear bodies Intensity

GENE INFORMATION

Gene name

 IDH1

Synonyms

Description

 Isocitrate dehydrogenase 1 (NADP+), soluble (HGNC Symbol)

Entrez gene summary

 Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

Chromosome

 2

Cytoband

 q34

Chromosome location (bp)

 208236227 - 208266074

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000138413 (version 83.38)

Entrez gene

 3417

UniProt

 O75874 (UniProt - Evidence at protein level)

neXtProt

 NX_O75874

Antibodypedia

 IDH1 antibodies

PROTEIN BROWSER
IDH1-001
IDH1-004
IDH1-006
IDH1-007
IDH1-008
IDH1-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IDH1-001
ENSP00000260985
ENST00000345146
O75874 [Direct mapping]
Isocitrate dehydrogenase [NADP] cytoplasmic
V9HWJ2 [Target identity:100%; Query identity:100%]
Isocitrate dehydrogenase [NADP]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004450 [isocitrate dehydrogenase (NADP+) activity]
GO:0005102 [receptor binding]
GO:0005737 [cytoplasm]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0005829 [cytosol]
GO:0006097 [glyoxylate cycle]
GO:0006099 [tricarboxylic acid cycle]
GO:0006102 [isocitrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006740 [NADPH regeneration]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0042803 [protein homodimerization activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 414 aa
46.7 kDa 		No 0
IDH1-004
ENSP00000410513
ENST00000446179
O75874 [Direct mapping]
Isocitrate dehydrogenase [NADP] cytoplasmic
V9HWJ2 [Target identity:100%; Query identity:100%]
Isocitrate dehydrogenase [NADP]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004450 [isocitrate dehydrogenase (NADP+) activity]
GO:0005102 [receptor binding]
GO:0005737 [cytoplasm]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0005829 [cytosol]
GO:0006097 [glyoxylate cycle]
GO:0006099 [tricarboxylic acid cycle]
GO:0006102 [isocitrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006740 [NADPH regeneration]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0042803 [protein homodimerization activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 414 aa
46.7 kDa 		No 0
IDH1-006
ENSP00000390265
ENST00000415913
O75874 [Direct mapping]
Isocitrate dehydrogenase [NADP] cytoplasmic
V9HWJ2 [Target identity:100%; Query identity:100%]
Isocitrate dehydrogenase [NADP]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004448 [isocitrate dehydrogenase activity]
GO:0004450 [isocitrate dehydrogenase (NADP+) activity]
GO:0005102 [receptor binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0005829 [cytosol]
GO:0006097 [glyoxylate cycle]
GO:0006099 [tricarboxylic acid cycle]
GO:0006102 [isocitrate metabolic process]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006740 [NADPH regeneration]
GO:0006749 [glutathione metabolic process]
GO:0006979 [response to oxidative stress]
GO:0008585 [female gonad development]
GO:0014070 [response to organic cyclic compound]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0042803 [protein homodimerization activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048545 [response to steroid hormone]
GO:0050661 [NADP binding]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0060696 [regulation of phospholipid catabolic process]
GO:0070062 [extracellular exosome]
GO:0071071 [regulation of phospholipid biosynthetic process]
Show all
 414 aa
46.7 kDa 		No 0
IDH1-007
ENSP00000396787
ENST00000451391
C9JJE5 [Direct mapping]
Isocitrate dehydrogenase [NADP] cytoplasmic
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004450 [isocitrate dehydrogenase (NADP+) activity]
GO:0006102 [isocitrate metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0055114 [oxidation-reduction process]
Show all
 62 aa
7.1 kDa 		No 0
IDH1-008
ENSP00000409045
ENST00000417583
C9JLU6 [Direct mapping]
Isocitrate dehydrogenase [NADP] cytoplasmic
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004450 [isocitrate dehydrogenase (NADP+) activity]
GO:0006102 [isocitrate metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0055114 [oxidation-reduction process]
Show all
 74 aa
8.3 kDa 		No 0
IDH1-009
ENSP00000391075
ENST00000415282
C9J4N6 [Direct mapping]
Isocitrate dehydrogenase [NADP] cytoplasmic
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004450 [isocitrate dehydrogenase (NADP+) activity]
GO:0006102 [isocitrate metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0055114 [oxidation-reduction process]
Show all
 157 aa
17.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.