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Malignant cells generally showed weak to moderate cytoplasmic positivity, often with a granular pattern. Most cases of malignant gliomas, cervical, skin and testicular cancers were negative.
GENE INFORMATION
Gene name
SPPL2A (HGNC Symbol)
Synonyms
IMP3, PSL2
Description
Signal peptide peptidase like 2A (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Feb 2012]