Cell atlas - SPPL2A - The Human Protein Atlas

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SPPL2A

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	SPPL2A
Gene description	Signal peptide peptidase like 2A
Protein class	Enzymes Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA067304
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles.

Main location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA067304	MCF7	Vesicles
	HPA067304	U-2 OS	Vesicles
	HPA067304	U-251 MG	Vesicles
	HPA067304	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	SPPL2A (HGNC Symbol)
Synonyms	IMP3, PSL2
Description	Signal peptide peptidase like 2A (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Feb 2012]
Chromosome	15
Cytoband	q21.2
Chromosome location (bp)	50702266 - 50765808
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138600 (version 83.38)
Entrez gene	84888
UniProt	Q8TCT8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TCT8
Antibodypedia	SPPL2A antibodies

PROTEIN BROWSER

SPPL2A-001	SPPL2A-003	SPPL2A-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPPL2A-001 ENSP00000261854 ENST00000261854	Q8TCT8 [Direct mapping] Signal peptide peptidase-like 2A Show all	Enzymes Peptidases Aspartic-type peptidases Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005770 [late endosome] GO:0006509 [membrane protein ectodomain proteolysis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030660 [Golgi-associated vesicle membrane] GO:0031293 [membrane protein intracellular domain proteolysis] GO:0031902 [late endosome membrane] GO:0033619 [membrane protein proteolysis] GO:0042500 [aspartic endopeptidase activity, intramembrane cleaving] GO:0042803 [protein homodimerization activity] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] GO:0071458 [integral component of cytoplasmic side of endoplasmic reticulum membrane] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] Show all	520 aa 58.1 kDa	Yes	9
SPPL2A-003 ENSP00000453932 ENST00000558414	H0YNA7 [Direct mapping] Signal peptide peptidase-like 2A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	150 aa 16.5 kDa	No	1
SPPL2A-004 ENSP00000453927 ENST00000558934	H0YNA2 [Direct mapping] Signal peptide peptidase-like 2A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	356 aa 40 kDa	No	8

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.