Expression of GPAT3 in cancer - Summary

CANCER ATLAS

Gene description

Glycerol-3-phosphate acyltransferase 3

Protein class

Enzymes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA029414

GENE INFORMATION
Gene name	GPAT3 (HGNC Symbol)
Synonyms	AGPAT10, AGPAT9, HMFN0839, LPAAT-theta, MAG1, MGC11324
Description	Glycerol-3-phosphate acyltransferase 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]
Chromosome	4
Cytoband	q21.23
Chromosome location (bp)	83535914 - 83605875
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000138678 (version 83.38)
Entrez gene	84803
UniProt	Q53EU6 (UniProt - Evidence at protein level)
neXtProt	NX_Q53EU6
Antibodypedia	GPAT3 antibodies

PROTEIN BROWSER

GPAT3-001	GPAT3-002	GPAT3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPAT3-001 ENSP00000378651 ENST00000395226	Q53EU6 [Direct mapping] Glycerol-3-phosphate acyltransferase 3 A0A024RDG5 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity] GO:0004366 [glycerol-3-phosphate O-acyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016024 [CDP-diacylglycerol biosynthetic process] GO:0016746 [transferase activity, transferring acyl groups] GO:0019432 [triglyceride biosynthetic process] GO:0032006 [regulation of TOR signaling] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	434 aa 48.7 kDa	No	2
GPAT3-002 ENSP00000264409 ENST00000264409	Q53EU6 [Direct mapping] Glycerol-3-phosphate acyltransferase 3 A0A024RDG5 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity] GO:0004366 [glycerol-3-phosphate O-acyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016024 [CDP-diacylglycerol biosynthetic process] GO:0016746 [transferase activity, transferring acyl groups] GO:0019432 [triglyceride biosynthetic process] GO:0032006 [regulation of TOR signaling] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	434 aa 48.7 kDa	No	2
GPAT3-201 ENSP00000482571 ENST00000611707	Q53EU6 [Direct mapping] Glycerol-3-phosphate acyltransferase 3 A0A024RDG5 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity] GO:0004366 [glycerol-3-phosphate O-acyltransferase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016024 [CDP-diacylglycerol biosynthetic process] GO:0016746 [transferase activity, transferring acyl groups] GO:0019432 [triglyceride biosynthetic process] GO:0032006 [regulation of TOR signaling] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	434 aa 48.7 kDa	No	2