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Several gliomas along with a few melanomas, renal, gastric and liver cancer showed moderate to strong nuclear positivity. Remaining cancers were negative.
GENE INFORMATION
Gene name
FGF2 (HGNC Symbol)
Synonyms
FGFB
Description
Fibroblast growth factor 2 (basic) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0000187 [activation of MAPK activity] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005125 [cytokine activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0006935 [chemotaxis] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009887 [organ morphogenesis] GO:0010764 [negative regulation of fibroblast migration] GO:0010863 [positive regulation of phospholipase C activity] GO:0014843 [growth factor dependent regulation of skeletal muscle satellite cell proliferation] GO:0030198 [extracellular matrix organization] GO:0030214 [hyaluronan catabolic process] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0032958 [inositol phosphate biosynthetic process] GO:0035019 [somatic stem cell population maintenance] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042056 [chemoattractant activity] GO:0042060 [wound healing] GO:0042660 [positive regulation of cell fate specification] GO:0043406 [positive regulation of MAP kinase activity] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0043537 [negative regulation of blood vessel endothelial cell migration] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0045087 [innate immune response] GO:0045765 [regulation of angiogenesis] GO:0045766 [positive regulation of angiogenesis] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048598 [embryonic morphogenesis] GO:0050918 [positive chemotaxis] GO:0051209 [release of sequestered calcium ion into cytosol] GO:0051781 [positive regulation of cell division] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0060548 [negative regulation of cell death] GO:0060591 [chondroblast differentiation] GO:0061045 [negative regulation of wound healing] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:1903672 [positive regulation of sprouting angiogenesis] GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor] GO:2000546 [positive regulation of endothelial cell chemotaxis to fibroblast growth factor]