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PLCZ1

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GENERAL INFORMATION

Gene name

 PLCZ1

Gene description

 Phospholipase C, zeta 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at transcript level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 PLCZ1 (HGNC Symbol)

Synonyms

 NYD-SP27, PLCzeta

Description

 Phospholipase C, zeta 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Chromosome

 12

Cytoband

 p12.3

Chromosome location (bp)

 18683169 - 18738057

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000139151 (version 83.38)

Entrez gene

 89869

UniProt

 Q86YW0 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q86YW0

Antibodypedia

 PLCZ1 antibodies

PROTEIN BROWSER
PLCZ1-001
PLCZ1-002
PLCZ1-004
PLCZ1-007
PLCZ1-009
PLCZ1-011
PLCZ1-018
PLCZ1-019
PLCZ1-022

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLCZ1-001
ENSP00000266505
ENST00000266505
Q86YW0 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006816 [calcium ion transport]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007343 [egg activation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 608 aa
70.4 kDa 		No 0
PLCZ1-002
ENSP00000445880
ENST00000538330
Q8N7S5 [Direct mapping]
Phosphoinositide phospholipase C
Show all
Predicted intracellular proteins
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006816 [calcium ion transport]
GO:0007165 [signal transduction]
GO:0007343 [egg activation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
Show all
 390 aa
44.8 kDa 		No 0
PLCZ1-004
ENSP00000445026
ENST00000539875
Q86YW0 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 415 aa
47.8 kDa 		No 0
PLCZ1-007
ENSP00000438629
ENST00000539072
F5H2D7 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Show all
Predicted intracellular proteins
Show all
GO:0004629 [phospholipase C activity]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006816 [calcium ion transport]
GO:0007343 [egg activation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0035556 [intracellular signal transduction]
Show all
 166 aa
18.9 kDa 		No 0
PLCZ1-009
ENSP00000444383
ENST00000541966
F5GZK3 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Show all
Predicted intracellular proteins
Show all
GO:0004629 [phospholipase C activity]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006816 [calcium ion transport]
GO:0007343 [egg activation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0035556 [intracellular signal transduction]
Show all
 76 aa
9.1 kDa 		No 0
PLCZ1-011
ENSP00000443762
ENST00000543242
F5H828 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Show all
Predicted intracellular proteins
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006816 [calcium ion transport]
GO:0007165 [signal transduction]
GO:0007343 [egg activation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0035556 [intracellular signal transduction]
Show all
 131 aa
14.9 kDa 		No 0
PLCZ1-018
ENSP00000438826
ENST00000534932
F5H3L4 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Show all
Predicted intracellular proteins
Show all
GO:0004629 [phospholipase C activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006816 [calcium ion transport]
GO:0007343 [egg activation]
GO:0008152 [metabolic process]
GO:0035556 [intracellular signal transduction]
Show all
 89 aa
10.4 kDa 		No 0
PLCZ1-019
ENSP00000438679
ENST00000536023
H0YFH9 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Show all
Predicted intracellular proteins
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006816 [calcium ion transport]
GO:0007165 [signal transduction]
GO:0007343 [egg activation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0035556 [intracellular signal transduction]
Show all
 101 aa
11.3 kDa 		No 0
PLCZ1-022
ENSP00000445889
ENST00000540421
H0YH40 [Direct mapping]
Phosphoinositide phospholipase C
Show all
Predicted intracellular proteins
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006816 [calcium ion transport]
GO:0007165 [signal transduction]
GO:0007343 [egg activation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
Show all
 266 aa
30.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.