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PLCZ1

GENERAL INFORMATION

Gene name

 PLCZ1

Gene description

 Phospholipase C, zeta 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at transcript level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 PLCZ1 (HGNC Symbol)

Synonyms

 NYD-SP27, PLCzeta

Description

 Phospholipase C, zeta 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Chromosome

 12

Cytoband

 p12.3

Chromosome location (bp)

 18683169 - 18738057

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000139151 (version 83.38)

Entrez gene

 89869

UniProt

 Q86YW0 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q86YW0

Antibodypedia

 PLCZ1 antibodies

PROTEIN BROWSER
PLCZ1-001
PLCZ1-002
PLCZ1-004
PLCZ1-007
PLCZ1-009
PLCZ1-011
PLCZ1-018
PLCZ1-019
PLCZ1-022

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLCZ1-001
ENSP00000266505
ENST00000266505
Q86YW0 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006816 [calcium ion transport]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007343 [egg activation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 608 aa
70.4 kDa 		No 0
PLCZ1-002
ENSP00000445880
ENST00000538330
Q8N7S5 [Direct mapping]
Phosphoinositide phospholipase C
Show all
Predicted intracellular proteins
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006816 [calcium ion transport]
GO:0007165 [signal transduction]
GO:0007343 [egg activation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
Show all
 390 aa
44.8 kDa 		No 0
PLCZ1-004
ENSP00000445026
ENST00000539875
Q86YW0 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 415 aa
47.8 kDa 		No 0
PLCZ1-007
ENSP00000438629
ENST00000539072
F5H2D7 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Show all
Predicted intracellular proteins
Show all
GO:0004629 [phospholipase C activity]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006816 [calcium ion transport]
GO:0007343 [egg activation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0035556 [intracellular signal transduction]
Show all
 166 aa
18.9 kDa 		No 0
PLCZ1-009
ENSP00000444383
ENST00000541966
F5GZK3 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Show all
Predicted intracellular proteins
Show all
GO:0004629 [phospholipase C activity]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006816 [calcium ion transport]
GO:0007343 [egg activation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0035556 [intracellular signal transduction]
Show all
 76 aa
9.1 kDa 		No 0
PLCZ1-011
ENSP00000443762
ENST00000543242
F5H828 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Show all
Predicted intracellular proteins
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006816 [calcium ion transport]
GO:0007165 [signal transduction]
GO:0007343 [egg activation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0035556 [intracellular signal transduction]
Show all
 131 aa
14.9 kDa 		No 0
PLCZ1-018
ENSP00000438826
ENST00000534932
F5H3L4 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Show all
Predicted intracellular proteins
Show all
GO:0004629 [phospholipase C activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006816 [calcium ion transport]
GO:0007343 [egg activation]
GO:0008152 [metabolic process]
GO:0035556 [intracellular signal transduction]
Show all
 89 aa
10.4 kDa 		No 0
PLCZ1-019
ENSP00000438679
ENST00000536023
H0YFH9 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Show all
Predicted intracellular proteins
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006816 [calcium ion transport]
GO:0007165 [signal transduction]
GO:0007343 [egg activation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0035556 [intracellular signal transduction]
Show all
 101 aa
11.3 kDa 		No 0
PLCZ1-022
ENSP00000445889
ENST00000540421
H0YH40 [Direct mapping]
Phosphoinositide phospholipase C
Show all
Predicted intracellular proteins
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0006816 [calcium ion transport]
GO:0007165 [signal transduction]
GO:0007343 [egg activation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
Show all
 266 aa
30.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.