Expression of LGR5 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Leucine-rich repeat containing G protein-coupled receptor 5

Protein class

G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA012530

GENE INFORMATION
Gene name	LGR5 (HGNC Symbol)
Synonyms	FEX, GPR49, GPR67, HG38
Description	Leucine-rich repeat containing G protein-coupled receptor 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Chromosome	12
Cytoband	q21.1
Chromosome location (bp)	71439770 - 71586310
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139292 (version 83.38)
Entrez gene	8549
UniProt	O75473 (UniProt - Evidence at protein level)
neXtProt	NX_O75473
Antibodypedia	LGR5 antibodies

PROTEIN BROWSER

LGR5-001	LGR5-003	LGR5-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LGR5-001 ENSP00000266674 ENST00000266674	O75473 [Direct mapping] Leucine-rich repeat-containing G-protein coupled receptor 5 A0A0A8K8C7 [Target identity:100%; Query identity:100%] G protein-coupled receptor 49; Leucine-rich repeat-containing G protein-coupled receptor 5, isoform CRA_b Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001942 [hair follicle development] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009994 [oocyte differentiation] GO:0016021 [integral component of membrane] GO:0032588 [trans-Golgi network membrane] GO:0042127 [regulation of cell proliferation] GO:0048839 [inner ear development] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis] Show all	907 aa 100 kDa	Yes	7
LGR5-003 ENSP00000443033 ENST00000536515	O75473 [Direct mapping] Leucine-rich repeat-containing G-protein coupled receptor 5 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0032588 [trans-Golgi network membrane] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	835 aa 92 kDa	Yes	7
LGR5-004 ENSP00000441035 ENST00000540815	O75473 [Direct mapping] Leucine-rich repeat-containing G-protein coupled receptor 5 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0032588 [trans-Golgi network membrane] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	883 aa 97.4 kDa	Yes	7