Tissue expression of LGR5 - Summary - The Human Protein Atlas

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LGR5

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	LGR5
Gene description	Leucine-rich repeat containing G protein-coupled receptor 5
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (placenta, fallopian tube)
GTEx:	Tissue enhanced (skeletal muscle)
FANTOM5:	Tissue enhanced (skeletal muscle, placenta)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA012530
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta, fallopian tube)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skeletal muscle)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skeletal muscle, placenta)

GENE INFORMATION
Gene name	LGR5 (HGNC Symbol)
Synonyms	FEX, GPR49, GPR67, HG38
Description	Leucine-rich repeat containing G protein-coupled receptor 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Chromosome	12
Cytoband	q21.1
Chromosome location (bp)	71439770 - 71586310
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139292 (version 83.38)
Entrez gene	8549
UniProt	O75473 (UniProt - Evidence at protein level)
neXtProt	NX_O75473
Antibodypedia	LGR5 antibodies

PROTEIN BROWSER

LGR5-001	LGR5-003	LGR5-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LGR5-001 ENSP00000266674 ENST00000266674	O75473 [Direct mapping] Leucine-rich repeat-containing G-protein coupled receptor 5 A0A0A8K8C7 [Target identity:100%; Query identity:100%] G protein-coupled receptor 49; Leucine-rich repeat-containing G protein-coupled receptor 5, isoform CRA_b Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001942 [hair follicle development] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009994 [oocyte differentiation] GO:0016021 [integral component of membrane] GO:0032588 [trans-Golgi network membrane] GO:0042127 [regulation of cell proliferation] GO:0048839 [inner ear development] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:2001013 [epithelial cell proliferation involved in renal tubule morphogenesis] Show all	907 aa 100 kDa	Yes	7
LGR5-003 ENSP00000443033 ENST00000536515	O75473 [Direct mapping] Leucine-rich repeat-containing G-protein coupled receptor 5 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0032588 [trans-Golgi network membrane] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	835 aa 92 kDa	Yes	7
LGR5-004 ENSP00000441035 ENST00000540815	O75473 [Direct mapping] Leucine-rich repeat-containing G-protein coupled receptor 5 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0032588 [trans-Golgi network membrane] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	883 aa 97.4 kDa	Yes	7

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.