Expression of FOXN4 in cancer - Summary

CANCER ATLAS

Gene description

Forkhead box N4

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA050018

GENE INFORMATION
Gene name	FOXN4
Synonyms
Description	Forkhead box N4 (HGNC Symbol)
Entrez gene summary	Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	q24.11
Chromosome location (bp)	109277979 - 109309220
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000139445 (version 83.38)
Entrez gene	121643
UniProt	Q96NZ1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96NZ1
Antibodypedia	FOXN4 antibodies

PROTEIN BROWSER

FOXN4-001	FOXN4-002	FOXN4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FOXN4-001 ENSP00000299162 ENST00000299162	Q96NZ1 [Direct mapping] Forkhead box protein N4 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0001158 [enhancer sequence-specific DNA binding] GO:0001947 [heart looping] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008016 [regulation of heart contraction] GO:0010842 [retina layer formation] GO:0030154 [cell differentiation] GO:0035881 [amacrine cell differentiation] GO:0036302 [atrioventricular canal development] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048663 [neuron fate commitment] GO:0060579 [ventral spinal cord interneuron fate commitment] Show all	517 aa 55.2 kDa	No	0
FOXN4-002 ENSP00000347354 ENST00000355216	Q96NZ1 [Direct mapping] Forkhead box protein N4 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0001158 [enhancer sequence-specific DNA binding] GO:0001947 [heart looping] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008016 [regulation of heart contraction] GO:0010842 [retina layer formation] GO:0035881 [amacrine cell differentiation] GO:0036302 [atrioventricular canal development] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0060579 [ventral spinal cord interneuron fate commitment] Show all	337 aa 36 kDa	No	0
FOXN4-005 ENSP00000474754 ENST00000468516	S4R3U5 [Direct mapping] Forkhead box protein N4 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	84 aa 9.4 kDa	No	0