Cell atlas - FOXN4 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

FOXN4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Mitochondria
	Nucleus

Human cell
	Cytosol
	Mitochondria
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	FOXN4
Gene description	Forkhead box N4
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & mitochondria. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (SCLC-21H, SH-SY5Y, U-266/70)
Protein evidence	Evidence at transcript level
Main location	Localized to the Nucleus (approved), Mitochondria (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA050018
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H, SH-SY5Y, U-266/70) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & mitochondria. In addition localized to the cytosol.

Main location

Nucleus (approved), Mitochondria (approved)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA050018	HEK 293	Nucleus
	HPA050018	HEK 293	Mitochondria
	HPA050018	SH-SY5Y	Nucleus
	HPA050018	SH-SY5Y	Mitochondria
	HPA050018	U-2 OS	Nucleus
			Mitochondria
			Cytosol

GENE INFORMATION
Gene name	FOXN4
Synonyms
Description	Forkhead box N4 (HGNC Symbol)
Entrez gene summary	Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	q24.11
Chromosome location (bp)	109277979 - 109309220
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000139445 (version 83.38)
Entrez gene	121643
UniProt	Q96NZ1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96NZ1
Antibodypedia	FOXN4 antibodies

PROTEIN BROWSER

FOXN4-001	FOXN4-002	FOXN4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FOXN4-001 ENSP00000299162 ENST00000299162	Q96NZ1 [Direct mapping] Forkhead box protein N4 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0001158 [enhancer sequence-specific DNA binding] GO:0001947 [heart looping] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008016 [regulation of heart contraction] GO:0010842 [retina layer formation] GO:0030154 [cell differentiation] GO:0035881 [amacrine cell differentiation] GO:0036302 [atrioventricular canal development] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048663 [neuron fate commitment] GO:0060579 [ventral spinal cord interneuron fate commitment] Show all	517 aa 55.2 kDa	No	0
FOXN4-002 ENSP00000347354 ENST00000355216	Q96NZ1 [Direct mapping] Forkhead box protein N4 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0001158 [enhancer sequence-specific DNA binding] GO:0001947 [heart looping] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008016 [regulation of heart contraction] GO:0010842 [retina layer formation] GO:0035881 [amacrine cell differentiation] GO:0036302 [atrioventricular canal development] GO:0043565 [sequence-specific DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0060579 [ventral spinal cord interneuron fate commitment] Show all	337 aa 36 kDa	No	0
FOXN4-005 ENSP00000474754 ENST00000468516	S4R3U5 [Direct mapping] Forkhead box protein N4 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	84 aa 9.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.