Expression of CERS5 in cancer - Summary - The Human Protein Atlas

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CERS5

TISSUE

CELL

CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

CANCER ATLAS

Gene description

Ceramide synthase 5

Protein class

Enzymes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA026589

GENE INFORMATION
Gene name	CERS5 (HGNC Symbol)
Synonyms	FLJ25304, LASS5, MGC45411, Trh4
Description	Ceramide synthase 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	12
Cytoband	q13.12
Chromosome location (bp)	50129306 - 50167533
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139624 (version 83.38)
Entrez gene	91012
UniProt	Q8N5B7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N5B7
Antibodypedia	CERS5 antibodies

PROTEIN BROWSER

CERS5-001	CERS5-016	CERS5-017	CERS5-019	CERS5-020	CERS5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CERS5-001 ENSP00000325485 ENST00000317551	Q8N5B7 [Direct mapping] Ceramide synthase 5 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006665 [sphingolipid metabolic process] GO:0016021 [integral component of membrane] GO:0030148 [sphingolipid biosynthetic process] GO:0031965 [nuclear membrane] GO:0044281 [small molecule metabolic process] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] Show all	392 aa 45.8 kDa	No	7
CERS5-016 ENSP00000447029 ENST00000550547	H0YHG4 [Direct mapping] Ceramide synthase 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] Show all	136 aa 15.8 kDa	No	4
CERS5-017 ENSP00000447266 ENST00000553122	H0YHK2 [Direct mapping] Ceramide synthase 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] Show all	111 aa 12.5 kDa	No	1
CERS5-019 ENSP00000449311 ENST00000550919	H0YIG1 [Direct mapping] Ceramide synthase 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] Show all	78 aa 9.2 kDa	No	1
CERS5-020 ENSP00000448295 ENST00000547800	H0YI10 [Direct mapping] Ceramide synthase 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] Show all	259 aa 30.5 kDa	No	4
CERS5-201 ENSP00000389050 ENST00000422340	Q8N5B7 [Direct mapping] Ceramide synthase 5 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006665 [sphingolipid metabolic process] GO:0016021 [integral component of membrane] GO:0030148 [sphingolipid biosynthetic process] GO:0031965 [nuclear membrane] GO:0044281 [small molecule metabolic process] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] Show all	334 aa 39.3 kDa	No	7

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.