Cell atlas - CERS5 - The Human Protein Atlas

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CERS5

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CERS5
Gene description	Ceramide synthase 5
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli. In addition localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)
Additional location	In addition localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA026589
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli. In addition localized to the nucleus.

Main location

Nucleoli (approved)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA026589	A-431	Nucleus
	HPA026589	A-431	Nucleoli
	HPA026589	U-2 OS	Nucleus
	HPA026589	U-2 OS	Nucleoli
	HPA026589	U-251 MG	Nucleus
	HPA026589	U-251 MG	Nucleoli

GENE INFORMATION
Gene name	CERS5 (HGNC Symbol)
Synonyms	FLJ25304, LASS5, MGC45411, Trh4
Description	Ceramide synthase 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	12
Cytoband	q13.12
Chromosome location (bp)	50129306 - 50167533
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139624 (version 83.38)
Entrez gene	91012
UniProt	Q8N5B7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N5B7
Antibodypedia	CERS5 antibodies

PROTEIN BROWSER

CERS5-001	CERS5-016	CERS5-017	CERS5-019	CERS5-020	CERS5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CERS5-001 ENSP00000325485 ENST00000317551	Q8N5B7 [Direct mapping] Ceramide synthase 5 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006665 [sphingolipid metabolic process] GO:0016021 [integral component of membrane] GO:0030148 [sphingolipid biosynthetic process] GO:0031965 [nuclear membrane] GO:0044281 [small molecule metabolic process] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] Show all	392 aa 45.8 kDa	No	7
CERS5-016 ENSP00000447029 ENST00000550547	H0YHG4 [Direct mapping] Ceramide synthase 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] Show all	136 aa 15.8 kDa	No	4
CERS5-017 ENSP00000447266 ENST00000553122	H0YHK2 [Direct mapping] Ceramide synthase 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] Show all	111 aa 12.5 kDa	No	1
CERS5-019 ENSP00000449311 ENST00000550919	H0YIG1 [Direct mapping] Ceramide synthase 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] Show all	78 aa 9.2 kDa	No	1
CERS5-020 ENSP00000448295 ENST00000547800	H0YI10 [Direct mapping] Ceramide synthase 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] Show all	259 aa 30.5 kDa	No	4
CERS5-201 ENSP00000389050 ENST00000422340	Q8N5B7 [Direct mapping] Ceramide synthase 5 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006665 [sphingolipid metabolic process] GO:0016021 [integral component of membrane] GO:0030148 [sphingolipid biosynthetic process] GO:0031965 [nuclear membrane] GO:0044281 [small molecule metabolic process] GO:0046513 [ceramide biosynthetic process] GO:0050291 [sphingosine N-acyltransferase activity] Show all	334 aa 39.3 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.