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Distinct cytoplasmic staining in breast and colorectal carcinomas. Several other adenocarcinomas were also distinctly stained. Nevertheless prostate and liver cancers, malignant melanomas and gliomas were mostly negative.
Malignant tissues showed cytoplasmic staining in variable intensity. Strongest staining in liver, thyroid, and breast cancers. Squamous cell carcinomas, renal cancers, malignant gliomas and lymphomas were mainly negative.
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008]
