Cell atlas - GALNT6 - The Human Protein Atlas

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GALNT6

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Nucleoplasm

Human cell
	Golgi Apparatus
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GALNT6
Gene description	Polypeptide N-acetylgalactosaminyltransferase 6
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus & nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA017086
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus & nucleoplasm.

Main location

Nucleoplasm (approved), Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017086	CACO-2	No staining
	HPA017086	MCF7	Nucleoplasm
	HPA017086	MCF7	Golgi apparatus

GENE INFORMATION
Gene name	GALNT6 (HGNC Symbol)
Synonyms	GalNAc-T6
Description	Polypeptide N-acetylgalactosaminyltransferase 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	51351247 - 51392867
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139629 (version 83.38)
Entrez gene	11226
UniProt	Q8NCL4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NCL4
Antibodypedia	GALNT6 antibodies

PROTEIN BROWSER

GALNT6-001	GALNT6-002	GALNT6-005	GALNT6-007	GALNT6-008	GALNT6-009	GALNT6-011	GALNT6-012	GALNT6-015	GALNT6-016	GALNT6-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GALNT6-001 ENSP00000348668 ENST00000356317	Q8NCL4 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 6 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004653 [polypeptide N-acetylgalactosaminyltransferase activity] GO:0005794 [Golgi apparatus] GO:0006493 [protein O-linked glycosylation] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0030246 [carbohydrate binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] Show all	622 aa 71.2 kDa	Yes	0
GALNT6-002 ENSP00000444171 ENST00000543196	Q8NCL4 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 6 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004653 [polypeptide N-acetylgalactosaminyltransferase activity] GO:0005794 [Golgi apparatus] GO:0006493 [protein O-linked glycosylation] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0030246 [carbohydrate binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0046872 [metal ion binding] GO:0048471 [perinuclear region of cytoplasm] Show all	622 aa 71.2 kDa	Yes	0
GALNT6-005 ENSP00000473918 ENST00000604426	S4R345 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 6 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		78 aa 9.2 kDa	Yes	0
GALNT6-007 ENSP00000473836 ENST00000605617	S4R310 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 6 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		69 aa 8.2 kDa	Yes	0
GALNT6-008 ENSP00000474101 ENST00000604381	S4R3A9 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 6 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		137 aa 15.9 kDa	Yes	0
GALNT6-009 ENSP00000474483 ENST00000605055	S4R3L4 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 6 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		23 aa 2.8 kDa	No	0
GALNT6-011 ENSP00000474515 ENST00000604847	S4R3M3 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 6 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		123 aa 14.2 kDa	Yes	0
GALNT6-012 ENSP00000474052 ENST00000603188	S4R396 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 6 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		62 aa 7.4 kDa	Yes	0
GALNT6-015 ENSP00000473948 ENST00000603563	S4R355 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 6 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		55 aa 6.6 kDa	Yes	0
GALNT6-016 ENSP00000473981 ENST00000605138	S4R370 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 6 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		39 aa 4.7 kDa	Yes	0
GALNT6-017 ENSP00000474163 ENST00000604506	S4R3L4 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 6 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		23 aa 2.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.