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ESD

CANCER ATLAS

Gene description

 Esterase D

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039700

GENE INFORMATION

Gene name

 ESD

Synonyms

Description

 Esterase D (HGNC Symbol)

Entrez gene summary

 This gene encodes a serine hydrolase that belongs to the esterase D family. The encoded enzyme is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. This gene is used as a genetic marker for retinoblastoma and Wilson's disease. [provided by RefSeq, Feb 2009]

Chromosome

 13

Cytoband

 q14.2

Chromosome location (bp)

 46771256 - 46797232

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139684 (version 83.38)

Entrez gene

 2098

UniProt

 P10768 (UniProt - Evidence at protein level)

neXtProt

 NX_P10768

Antibodypedia

 ESD antibodies

PROTEIN BROWSER
ESD-001
ESD-003
ESD-004
ESD-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ESD-001
ENSP00000367992
ENST00000378720
P10768 [Direct mapping]
S-formylglutathione hydrolase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0008150 [biological_process]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0018738 [S-formylglutathione hydrolase activity]
GO:0044281 [small molecule metabolic process]
GO:0046294 [formaldehyde catabolic process]
GO:0047374 [methylumbelliferyl-acetate deacetylase activity]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0070062 [extracellular exosome]
GO:1901687 [glutathione derivative biosynthetic process]
Show all
 282 aa
31.5 kDa 		No 0
ESD-003
ENSP00000367969
ENST00000378697
X6RA14 [Direct mapping]
S-formylglutathione hydrolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0018738 [S-formylglutathione hydrolase activity]
GO:0046294 [formaldehyde catabolic process]
Show all
 253 aa
28.2 kDa 		No 0
ESD-004
ENSP00000391350
ENST00000412582
H7BZT7 [Direct mapping]
S-formylglutathione hydrolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0018738 [S-formylglutathione hydrolase activity]
GO:0046294 [formaldehyde catabolic process]
Show all
 230 aa
25.4 kDa 		No 0
ESD-005
ENSP00000476193
ENST00000471867
U3KQT1 [Direct mapping]
S-formylglutathione hydrolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0018738 [S-formylglutathione hydrolase activity]
GO:0046294 [formaldehyde catabolic process]
Show all
 120 aa
13 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.