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ESD

GENERAL INFORMATION

Gene name

 ESD

Gene description

 Esterase D

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in a majority of the tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA039700
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ESD

Synonyms

Description

 Esterase D (HGNC Symbol)

Entrez gene summary

 This gene encodes a serine hydrolase that belongs to the esterase D family. The encoded enzyme is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. This gene is used as a genetic marker for retinoblastoma and Wilson's disease. [provided by RefSeq, Feb 2009]

Chromosome

 13

Cytoband

 q14.2

Chromosome location (bp)

 46771256 - 46797232

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139684 (version 83.38)

Entrez gene

 2098

UniProt

 P10768 (UniProt - Evidence at protein level)

neXtProt

 NX_P10768

Antibodypedia

 ESD antibodies

PROTEIN BROWSER
ESD-001
ESD-003
ESD-004
ESD-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ESD-001
ENSP00000367992
ENST00000378720
P10768 [Direct mapping]
S-formylglutathione hydrolase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0008150 [biological_process]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016788 [hydrolase activity, acting on ester bonds]
GO:0018738 [S-formylglutathione hydrolase activity]
GO:0044281 [small molecule metabolic process]
GO:0046294 [formaldehyde catabolic process]
GO:0047374 [methylumbelliferyl-acetate deacetylase activity]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0070062 [extracellular exosome]
GO:1901687 [glutathione derivative biosynthetic process]
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 282 aa
31.5 kDa 		No 0
ESD-003
ENSP00000367969
ENST00000378697
X6RA14 [Direct mapping]
S-formylglutathione hydrolase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0018738 [S-formylglutathione hydrolase activity]
GO:0046294 [formaldehyde catabolic process]
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 253 aa
28.2 kDa 		No 0
ESD-004
ENSP00000391350
ENST00000412582
H7BZT7 [Direct mapping]
S-formylglutathione hydrolase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0018738 [S-formylglutathione hydrolase activity]
GO:0046294 [formaldehyde catabolic process]
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 230 aa
25.4 kDa 		No 0
ESD-005
ENSP00000476193
ENST00000471867
U3KQT1 [Direct mapping]
S-formylglutathione hydrolase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0018738 [S-formylglutathione hydrolase activity]
GO:0046294 [formaldehyde catabolic process]
Show all
 120 aa
13 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.