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Moderate to strong nuclear staining was observed in a fraction of cells in most cancer tissues. Prostate and liver cancers were weakly stained or negative in most cases.
GENE INFORMATION
Gene name
RB1 (HGNC Symbol)
Synonyms
OSRC, PPP1R130, RB
Description
Retinoblastoma 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]