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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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RB1
  • TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

RB1

Gene description

Retinoblastoma 1

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in most tissues, including retina.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA050082 , CAB016687
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Eye
N/A
Retina
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Retina

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

RB1 (HGNC Symbol)

Synonyms

OSRC, PPP1R130, RB

Description

Retinoblastoma 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

Chromosome

13

Cytoband

q14.2

Chromosome location (bp)

48303751 - 48481986

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000139687 (version 83.38)

Entrez gene

5925

UniProt

P06400 (UniProt - Evidence at protein level)

neXtProt

NX_P06400

Antibodypedia

RB1 antibodies

PROTEIN BROWSER

RB1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RB1-002
ENSP00000267163
ENST00000267163
P06400 [Direct mapping]
Retinoblastoma-associated protein
A0A024RDV3 [Target identity:100%; Query identity:100%]
Retinoblastoma 1 (Including osteosarcoma), isoform CRA_a
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000075 [cell cycle checkpoint]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000278 [mitotic cell cycle]
GO:0000785 [chromatin]
GO:0001047 [core promoter binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005819 [spindle]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007050 [cell cycle arrest]
GO:0007070 [negative regulation of transcription from RNA polymerase II promoter during mitosis]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0007265 [Ras protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0016032 [viral process]
GO:0016514 [SWI/SNF complex]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0030182 [neuron differentiation]
GO:0030521 [androgen receptor signaling pathway]
GO:0031134 [sister chromatid biorientation]
GO:0031175 [neuron projection development]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034088 [maintenance of mitotic sister chromatid cohesion]
GO:0034349 [glial cell apoptotic process]
GO:0035189 [Rb-E2F complex]
GO:0035914 [skeletal muscle cell differentiation]
GO:0042551 [neuron maturation]
GO:0042802 [identical protein binding]
GO:0043353 [enucleate erythrocyte differentiation]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043550 [regulation of lipid kinase activity]
GO:0045445 [myoblast differentiation]
GO:0045651 [positive regulation of macrophage differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0045842 [positive regulation of mitotic metaphase/anaphase transition]
GO:0045879 [negative regulation of smoothened signaling pathway]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048565 [digestive tract development]
GO:0048667 [cell morphogenesis involved in neuron differentiation]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050681 [androgen receptor binding]
GO:0051146 [striated muscle cell differentiation]
GO:0051219 [phosphoprotein binding]
GO:0051301 [cell division]
GO:0051402 [neuron apoptotic process]
GO:0051726 [regulation of cell cycle]
GO:0071459 [protein localization to chromosome, centromeric region]
GO:0071466 [cellular response to xenobiotic stimulus]
GO:0071922 [regulation of cohesin localization to chromatin]
GO:0071930 [negative regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0090230 [regulation of centromere complex assembly]
GO:0097284 [hepatocyte apoptotic process]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
928 aa
106.2 kDa
No 0

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