Tissue expression of RTN1 - Summary - The Human Protein Atlas

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RTN1

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TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	RTN1
Gene description	Reticulon 1
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (cerebellum, cerebral cortex, hypothalamus, hippocampus, caudate, pituitary gland)
FANTOM5:	Group enriched (brain, cerebellum, hippocampus, caudate, pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in CNS and islets of Langerhans.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA044249 , CAB002745
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebellum, cerebral cortex, hypothalamus, hippocampus, caudate, pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (brain, cerebellum, hippocampus, caudate, pituitary gland)

GENE INFORMATION
Gene name	RTN1 (HGNC Symbol)
Synonyms	NSP
Description	Reticulon 1 (HGNC Symbol)
Entrez gene summary	This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]
Chromosome	14
Cytoband	q23.1
Chromosome location (bp)	59595976 - 59870966
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139970 (version 83.38)
Entrez gene	6252
UniProt	Q16799 (UniProt - Evidence at protein level)
neXtProt	NX_Q16799
Antibodypedia	RTN1 antibodies

PROTEIN BROWSER

RTN1-001	RTN1-002	RTN1-003	RTN1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RTN1-001 ENSP00000267484 ENST00000267484	Q16799 [Direct mapping] Reticulon-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0012505 [endomembrane system] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030182 [neuron differentiation] Show all	776 aa 83.6 kDa	No	2
RTN1-002 ENSP00000340716 ENST00000342503	Q16799 [Direct mapping] Reticulon-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0012505 [endomembrane system] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030182 [neuron differentiation] Show all	208 aa 23.6 kDa	No	2
RTN1-003 ENSP00000378525 ENST00000395090	A8MT72 [Direct mapping] Reticulon Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] Show all	193 aa 21.9 kDa	No	2
RTN1-201 ENSP00000483039 ENST00000611068	Q2NKQ5 [Direct mapping] Reticulon Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] Show all	702 aa 76.2 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.