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ADAM21

CANCER ATLAS

Gene description

 ADAM metallopeptidase domain 21

Protein class

 Enzymes, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA059016

GENE INFORMATION

Gene name

 ADAM21 (HGNC Symbol)

Synonyms

 ADAM31

Description

 ADAM metallopeptidase domain 21 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene expression is testis-specific. [provided by RefSeq, May 2011]

Chromosome

 14

Cytoband

 q24.2

Chromosome location (bp)

 70452157 - 70459899

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139985 (version 83.38)

Entrez gene

 8747

UniProt

 Q9UKJ8 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UKJ8

Antibodypedia

 ADAM21 antibodies

PROTEIN BROWSER
ADAM21-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAM21-001
ENSP00000474385
ENST00000603540
Q9UKJ8 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 21
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Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007338 [single fertilization]
GO:0007339 [binding of sperm to zona pellucida]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0030424 [axon]
GO:0032504 [multicellular organism reproduction]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
Show all
 722 aa
80.8 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.