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ADAM21

GENERAL INFORMATION

Gene name

 ADAM21

Gene description

 ADAM metallopeptidase domain 21

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in Leydig cells in testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA059016
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 ADAM21 (HGNC Symbol)

Synonyms

 ADAM31

Description

 ADAM metallopeptidase domain 21 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene expression is testis-specific. [provided by RefSeq, May 2011]

Chromosome

 14

Cytoband

 q24.2

Chromosome location (bp)

 70452157 - 70459899

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139985 (version 83.38)

Entrez gene

 8747

UniProt

 Q9UKJ8 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UKJ8

Antibodypedia

 ADAM21 antibodies

PROTEIN BROWSER
ADAM21-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAM21-001
ENSP00000474385
ENST00000603540
Q9UKJ8 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 21
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Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0004222 [metalloendopeptidase activity]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007338 [single fertilization]
GO:0007339 [binding of sperm to zona pellucida]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0030424 [axon]
GO:0032504 [multicellular organism reproduction]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
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 722 aa
80.8 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.