Expression of KCNH5 in cancer - Summary

CANCER ATLAS

Gene description

Potassium channel, voltage gated eag related subfamily H, member 5

Protein class

Predicted membrane proteins, Voltage-gated ion channels

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA030487

GENE INFORMATION
Gene name	KCNH5 (HGNC Symbol)
Synonyms	eag2, H-EAG2, Kv10.2
Description	Potassium channel, voltage gated eag related subfamily H, member 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	14
Cytoband	q23.2
Chromosome location (bp)	62699454 - 63102037
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140015 (version 83.38)
Entrez gene	27133
UniProt	Q8NCM2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NCM2
Antibodypedia	KCNH5 antibodies

PROTEIN BROWSER

KCNH5-003	KCNH5-004	KCNH5-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNH5-003 ENSP00000378419 ENST00000394968	Q8NCM2 [Direct mapping] Potassium voltage-gated channel subfamily H member 5 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0000155 [phosphorelay sensor kinase activity] GO:0000160 [phosphorelay signal transduction system] GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005516 [calmodulin binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0009986 [cell surface] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0016020 [membrane] GO:0023014 [signal transduction by protein phosphorylation] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	624 aa 71.1 kDa	No	6
KCNH5-004 ENSP00000321427 ENST00000322893	Q8NCM2 [Direct mapping] Potassium voltage-gated channel subfamily H member 5 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0000155 [phosphorelay sensor kinase activity] GO:0000160 [phosphorelay signal transduction system] GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005516 [calmodulin binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0009986 [cell surface] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0016020 [membrane] GO:0023014 [signal transduction by protein phosphorylation] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0044325 [ion channel binding] GO:0046982 [protein heterodimerization activity] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	988 aa 111.9 kDa	No	6
KCNH5-005 ENSP00000395439 ENST00000420622	Q8NCM2 [Direct mapping] Potassium voltage-gated channel subfamily H member 5 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0000155 [phosphorelay sensor kinase activity] GO:0000160 [phosphorelay signal transduction system] GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005516 [calmodulin binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0009986 [cell surface] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0016020 [membrane] GO:0023014 [signal transduction by protein phosphorylation] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	611 aa 69.4 kDa	No	6