Tissue expression of KCNH5 - Summary - The Human Protein Atlas

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KCNH5

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	KCNH5
Gene description	Potassium channel, voltage gated eag related subfamily H, member 5
Protein class	Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex, adrenal gland)
GTEx:	Not detected
FANTOM5:	Group enriched (retina, brain, hippocampus)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA030487
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

Skeletal muscle

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, adrenal gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Not detected
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (retina, brain, hippocampus)

GENE INFORMATION
Gene name	KCNH5 (HGNC Symbol)
Synonyms	eag2, H-EAG2, Kv10.2
Description	Potassium channel, voltage gated eag related subfamily H, member 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	14
Cytoband	q23.2
Chromosome location (bp)	62699454 - 63102037
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140015 (version 83.38)
Entrez gene	27133
UniProt	Q8NCM2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NCM2
Antibodypedia	KCNH5 antibodies

PROTEIN BROWSER

KCNH5-003	KCNH5-004	KCNH5-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNH5-003 ENSP00000378419 ENST00000394968	Q8NCM2 [Direct mapping] Potassium voltage-gated channel subfamily H member 5 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0000155 [phosphorelay sensor kinase activity] GO:0000160 [phosphorelay signal transduction system] GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005516 [calmodulin binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0009986 [cell surface] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0016020 [membrane] GO:0023014 [signal transduction by protein phosphorylation] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	624 aa 71.1 kDa	No	6
KCNH5-004 ENSP00000321427 ENST00000322893	Q8NCM2 [Direct mapping] Potassium voltage-gated channel subfamily H member 5 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0000155 [phosphorelay sensor kinase activity] GO:0000160 [phosphorelay signal transduction system] GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005516 [calmodulin binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0009986 [cell surface] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0016020 [membrane] GO:0023014 [signal transduction by protein phosphorylation] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0044325 [ion channel binding] GO:0046982 [protein heterodimerization activity] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	988 aa 111.9 kDa	No	6
KCNH5-005 ENSP00000395439 ENST00000420622	Q8NCM2 [Direct mapping] Potassium voltage-gated channel subfamily H member 5 Show all	Voltage-gated ion channels Voltage-Gated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0000155 [phosphorelay sensor kinase activity] GO:0000160 [phosphorelay signal transduction system] GO:0005216 [ion channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005516 [calmodulin binding] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0009986 [cell surface] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0016020 [membrane] GO:0023014 [signal transduction by protein phosphorylation] GO:0034765 [regulation of ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	611 aa 69.4 kDa	No	6

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.