Cell atlas - SLC24A4 - The Human Protein Atlas

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SLC24A4

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SLC24A4
Gene description	Solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SLC24A4 (HGNC Symbol)
Synonyms	NCKX4
Description	Solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
Chromosome	14
Cytoband	q32.12
Chromosome location (bp)	92322581 - 92501483
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140090 (version 83.38)
Entrez gene	123041
UniProt	Q8NFF2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NFF2
Antibodypedia	SLC24A4 antibodies

PROTEIN BROWSER

SLC24A4-001	SLC24A4-002	SLC24A4-003	SLC24A4-007	SLC24A4-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC24A4-001 ENSP00000431840 ENST00000532405	Q8NFF2 [Direct mapping] Sodium/potassium/calcium exchanger 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005509 [calcium ion binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007608 [sensory perception of smell] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030955 [potassium ion binding] GO:0031402 [sodium ion binding] GO:0035725 [sodium ion transmembrane transport] GO:0050896 [response to stimulus] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0097186 [amelogenesis] Show all	622 aa 69 kDa	No	>9
SLC24A4-002 ENSP00000433302 ENST00000531433	Q8NFF2 [Direct mapping] Sodium/potassium/calcium exchanger 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005509 [calcium ion binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007608 [sensory perception of smell] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030955 [potassium ion binding] GO:0031402 [sodium ion binding] GO:0035725 [sodium ion transmembrane transport] GO:0050896 [response to stimulus] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0097186 [amelogenesis] Show all	603 aa 67 kDa	No	>9
SLC24A4-003 ENSP00000376948 ENST00000393265	Q8NFF2 [Direct mapping] Sodium/potassium/calcium exchanger 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005509 [calcium ion binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007608 [sensory perception of smell] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030955 [potassium ion binding] GO:0031402 [sodium ion binding] GO:0035725 [sodium ion transmembrane transport] GO:0050896 [response to stimulus] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0097186 [amelogenesis] Show all	558 aa 61.9 kDa	No	>9
SLC24A4-007 ENSP00000432464 ENST00000525557	H0YCX3 [Direct mapping] Sodium/potassium/calcium exchanger 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005887 [integral component of plasma membrane] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	464 aa 51.1 kDa	No	8
SLC24A4-009 ENSP00000452099 ENST00000554461	G3V505 [Direct mapping] Sodium/potassium/calcium exchanger 4 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005887 [integral component of plasma membrane] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	64 aa 6.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.