Tissue expression of SLC24A4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC24A4
Gene description	Solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Tissue enhanced (cerebral cortex)
FANTOM5:	Tissue enhanced (retina, hippocampus)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (retina, hippocampus)

GENE INFORMATION
Gene name	SLC24A4 (HGNC Symbol)
Synonyms	NCKX4
Description	Solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
Chromosome	14
Cytoband	q32.12
Chromosome location (bp)	92322581 - 92501483
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140090 (version 83.38)
Entrez gene	123041
UniProt	Q8NFF2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NFF2
Antibodypedia	SLC24A4 antibodies

PROTEIN BROWSER

SLC24A4-001	SLC24A4-002	SLC24A4-003	SLC24A4-007	SLC24A4-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC24A4-001 ENSP00000431840 ENST00000532405	Q8NFF2 [Direct mapping] Sodium/potassium/calcium exchanger 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005509 [calcium ion binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007608 [sensory perception of smell] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030955 [potassium ion binding] GO:0031402 [sodium ion binding] GO:0035725 [sodium ion transmembrane transport] GO:0050896 [response to stimulus] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0097186 [amelogenesis] Show all	622 aa 69 kDa	No	>9
SLC24A4-002 ENSP00000433302 ENST00000531433	Q8NFF2 [Direct mapping] Sodium/potassium/calcium exchanger 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005509 [calcium ion binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007608 [sensory perception of smell] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030955 [potassium ion binding] GO:0031402 [sodium ion binding] GO:0035725 [sodium ion transmembrane transport] GO:0050896 [response to stimulus] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0097186 [amelogenesis] Show all	603 aa 67 kDa	No	>9
SLC24A4-003 ENSP00000376948 ENST00000393265	Q8NFF2 [Direct mapping] Sodium/potassium/calcium exchanger 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005262 [calcium channel activity] GO:0005509 [calcium ion binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006813 [potassium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0007608 [sensory perception of smell] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0015293 [symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030955 [potassium ion binding] GO:0031402 [sodium ion binding] GO:0035725 [sodium ion transmembrane transport] GO:0050896 [response to stimulus] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0097186 [amelogenesis] Show all	558 aa 61.9 kDa	No	>9
SLC24A4-007 ENSP00000432464 ENST00000525557	H0YCX3 [Direct mapping] Sodium/potassium/calcium exchanger 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Show all	GO:0005887 [integral component of plasma membrane] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	464 aa 51.1 kDa	No	8
SLC24A4-009 ENSP00000452099 ENST00000554461	G3V505 [Direct mapping] Sodium/potassium/calcium exchanger 4 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005887 [integral component of plasma membrane] GO:0008273 [calcium, potassium:sodium antiporter activity] GO:0016021 [integral component of membrane] GO:0035725 [sodium ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	64 aa 6.8 kDa	No	0