Cell atlas - SERPINA10 - The Human Protein Atlas

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SERPINA10

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SERPINA10
Gene description	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
Protein class	Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Cell line enriched (Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA048739
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (approved)

Additional location

Cytosol (approved)

1 HPA048739: Hep G2	2 HPA048739: Hep G2	3 HPA048739: U-2 OS
	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
1 2	HPA048739	Hep G2	Nucleoplasm
1 2	HPA048739	Hep G2	Cytosol
3	HPA048739	U-2 OS	No staining

GENE INFORMATION
Gene name	SERPINA10 (HGNC Symbol)
Synonyms	PZI, ZPI
Description	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]
Chromosome	14
Cytoband	q32.13
Chromosome location (bp)	94280455 - 94293271
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140093 (version 83.38)
Entrez gene	51156
UniProt	Q9UK55 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UK55
Antibodypedia	SERPINA10 antibodies

PROTEIN BROWSER

SERPINA10-001	SERPINA10-002	SERPINA10-003	SERPINA10-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINA10-001 ENSP00000261994 ENST00000261994	Q9UK55 [Direct mapping] Protein Z-dependent protease inhibitor A0A024R6I6 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 10, isoform CRA_b Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0007596 [blood coagulation] GO:0008201 [heparin binding] GO:0008218 [bioluminescence] GO:0010951 [negative regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	444 aa 50.7 kDa	Yes	0
SERPINA10-002 ENSP00000450896 ENST00000554723	G3V2W1 [Direct mapping] Protein Z-dependent protease inhibitor; Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 10, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	484 aa 55.1 kDa	No	1
SERPINA10-003 ENSP00000450971 ENST00000554173	Q9UK55 [Direct mapping] Protein Z-dependent protease inhibitor A0A024R6I6 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 10, isoform CRA_b Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0007596 [blood coagulation] GO:0008201 [heparin binding] GO:0008218 [bioluminescence] GO:0010951 [negative regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	444 aa 50.7 kDa	Yes	0
SERPINA10-201 ENSP00000376809 ENST00000393096	Q9UK55 [Direct mapping] Protein Z-dependent protease inhibitor A0A024R6I6 [Target identity:100%; Query identity:100%] Serpin peptidase inhibitor, clade A (Alpha-1 antiproteinase, antitrypsin), member 10, isoform CRA_b Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0007596 [blood coagulation] GO:0008201 [heparin binding] GO:0008218 [bioluminescence] GO:0010951 [negative regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	444 aa 50.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.