Cell atlas - HDC - The Human Protein Atlas

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HDC

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	HDC
Gene description	Histidine decarboxylase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (HMC-1, HEL)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HMC-1, HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	HDC
Synonyms
Description	Histidine decarboxylase (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]
Chromosome	15
Cytoband	q21.2
Chromosome location (bp)	50241947 - 50266026
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140287 (version 83.38)
Entrez gene	3067
UniProt	P19113 (UniProt - Evidence at protein level)
neXtProt	NX_P19113
Antibodypedia	HDC antibodies

PROTEIN BROWSER

HDC-001	HDC-004	HDC-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HDC-001 ENSP00000267845 ENST00000267845	P19113 [Direct mapping] Histidine decarboxylase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Show all	GO:0001694 [histamine biosynthetic process] GO:0004398 [histidine decarboxylase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006547 [histidine metabolic process] GO:0006548 [histidine catabolic process] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042423 [catecholamine biosynthetic process] GO:0044281 [small molecule metabolic process] Show all	662 aa 74.1 kDa	No	0
HDC-004 ENSP00000440252 ENST00000543581	P19113 [Direct mapping] Histidine decarboxylase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Show all	GO:0001694 [histamine biosynthetic process] GO:0004398 [histidine decarboxylase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006547 [histidine metabolic process] GO:0006548 [histidine catabolic process] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030170 [pyridoxal phosphate binding] GO:0034641 [cellular nitrogen compound metabolic process] GO:0042423 [catecholamine biosynthetic process] GO:0044281 [small molecule metabolic process] Show all	629 aa 70.1 kDa	No	0
HDC-007 ENSP00000453183 ENST00000559683	H0YLF0 [Direct mapping] Histidine decarboxylase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0006520 [cellular amino acid metabolic process] GO:0016831 [carboxy-lyase activity] GO:0019752 [carboxylic acid metabolic process] GO:0030170 [pyridoxal phosphate binding] Show all	179 aa 20 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.