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HDC

GENERAL INFORMATION

Gene name

 HDC

Gene description

 Histidine decarboxylase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (epididymis)
GTEx:Tissue enhanced (hypothalamus)
FANTOM5:Tissue enriched (epididymis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression, most abundant in gastrointestinal tract and lung.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA038891
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (epididymis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (epididymis)

GENE INFORMATION

Gene name

 HDC

Synonyms

Description

 Histidine decarboxylase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]

Chromosome

 15

Cytoband

 q21.2

Chromosome location (bp)

 50241947 - 50266026

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140287 (version 83.38)

Entrez gene

 3067

UniProt

 P19113 (UniProt - Evidence at protein level)

neXtProt

 NX_P19113

Antibodypedia

 HDC antibodies

PROTEIN BROWSER
HDC-001
HDC-004
HDC-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HDC-001
ENSP00000267845
ENST00000267845
P19113 [Direct mapping]
Histidine decarboxylase
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Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Show all
GO:0001694 [histamine biosynthetic process]
GO:0004398 [histidine decarboxylase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006547 [histidine metabolic process]
GO:0006548 [histidine catabolic process]
GO:0016831 [carboxy-lyase activity]
GO:0019752 [carboxylic acid metabolic process]
GO:0030170 [pyridoxal phosphate binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042423 [catecholamine biosynthetic process]
GO:0044281 [small molecule metabolic process]
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 662 aa
74.1 kDa 		No 0
HDC-004
ENSP00000440252
ENST00000543581
P19113 [Direct mapping]
Histidine decarboxylase
Show all
Enzymes
   ENZYME proteins
   Lyases
Predicted intracellular proteins
Show all
GO:0001694 [histamine biosynthetic process]
GO:0004398 [histidine decarboxylase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006547 [histidine metabolic process]
GO:0006548 [histidine catabolic process]
GO:0016831 [carboxy-lyase activity]
GO:0019752 [carboxylic acid metabolic process]
GO:0030170 [pyridoxal phosphate binding]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042423 [catecholamine biosynthetic process]
GO:0044281 [small molecule metabolic process]
Show all
 629 aa
70.1 kDa 		No 0
HDC-007
ENSP00000453183
ENST00000559683
H0YLF0 [Direct mapping]
Histidine decarboxylase
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0006520 [cellular amino acid metabolic process]
GO:0016831 [carboxy-lyase activity]
GO:0019752 [carboxylic acid metabolic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
 179 aa
20 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.