Expression of NTRK3 in cancer - Summary

CANCER ATLAS

Gene description

Neurotrophic tyrosine kinase, receptor, type 3

Protein class

Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB009233

GENE INFORMATION
Gene name	NTRK3 (HGNC Symbol)
Synonyms	TRKC
Description	Neurotrophic tyrosine kinase, receptor, type 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Chromosome	15
Cytoband	q25.3
Chromosome location (bp)	87859751 - 88256768
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140538 (version 83.38)
Entrez gene	4916
UniProt	Q16288 (UniProt - Evidence at protein level)
neXtProt	NX_Q16288
Antibodypedia	NTRK3 antibodies

PROTEIN BROWSER

NTRK3-001	NTRK3-002	NTRK3-003	NTRK3-004	NTRK3-005	NTRK3-007	NTRK3-010	NTRK3-015	NTRK3-018	NTRK3-019	NTRK3-201	NTRK3-202	NTRK3-203	NTRK3-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NTRK3-001 ENSP00000377990 ENST00000394480	Q16288 [Direct mapping] NT-3 growth factor receptor X5D7M5 [Target identity:100%; Query identity:100%] Tyrosine-protein kinase receptor Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007507 [heart development] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030335 [positive regulation of cell migration] GO:0032148 [activation of protein kinase B activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0038179 [neurotrophin signaling pathway] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0050927 [positive regulation of positive chemotaxis] GO:0090630 [activation of GTPase activity] GO:2000251 [positive regulation of actin cytoskeleton reorganization] Show all	825 aa 92.8 kDa	Yes	1
NTRK3-002 ENSP00000318328 ENST00000317501	Q16288 [Direct mapping] NT-3 growth factor receptor Q96CY4 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 3; Neurotrophic tyrosine kinase, receptor, type 3, isoform CRA_e Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007507 [heart development] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030335 [positive regulation of cell migration] GO:0032148 [activation of protein kinase B activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0038179 [neurotrophin signaling pathway] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0050927 [positive regulation of positive chemotaxis] GO:0090630 [activation of GTPase activity] GO:2000251 [positive regulation of actin cytoskeleton reorganization] Show all	612 aa 68.5 kDa	Yes	1
NTRK3-003 ENSP00000437773 ENST00000542733	B7Z7U4 [Direct mapping] Tyrosine-protein kinase receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0038179 [neurotrophin signaling pathway] Show all	617 aa 69 kDa	No	1
NTRK3-004 ENSP00000453959 ENST00000557856	Q16288 [Direct mapping] NT-3 growth factor receptor X5DNW6 [Target identity:100%; Query identity:100%] Tyrosine-protein kinase receptor Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007507 [heart development] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030335 [positive regulation of cell migration] GO:0032148 [activation of protein kinase B activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0038179 [neurotrophin signaling pathway] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0050927 [positive regulation of positive chemotaxis] GO:0090630 [activation of GTPase activity] GO:2000251 [positive regulation of actin cytoskeleton reorganization] Show all	817 aa 91.8 kDa	Yes	1
NTRK3-005 ENSP00000473656 ENST00000559188	R4GNH5 [Direct mapping] NT-3 growth factor receptor Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	90 aa 10.7 kDa	No	0
NTRK3-007 ENSP00000473315 ENST00000558576	R4GMR8 [Direct mapping] NT-3 growth factor receptor Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] Show all	146 aa 16.2 kDa	No	0
NTRK3-010 ENSP00000473475 ENST00000560017	R4GN40 [Direct mapping] NT-3 growth factor receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	85 aa 9.1 kDa	No	1
NTRK3-015 ENSP00000453511 ENST00000558676	H0YM90 [Direct mapping] Tyrosine-protein kinase receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0038179 [neurotrophin signaling pathway] Show all	705 aa 78.6 kDa	Yes	1
NTRK3-018 ENSP00000485864 ENST00000629765	Q16288 [Direct mapping] NT-3 growth factor receptor X5D2R1 [Target identity:100%; Query identity:100%] Tyrosine-protein kinase receptor Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007507 [heart development] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030335 [positive regulation of cell migration] GO:0032148 [activation of protein kinase B activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0038179 [neurotrophin signaling pathway] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0050927 [positive regulation of positive chemotaxis] GO:0090630 [activation of GTPase activity] GO:2000251 [positive regulation of actin cytoskeleton reorganization] Show all	839 aa 94.4 kDa	Yes	1
NTRK3-019 ENSP00000486784 ENST00000626019	A0A0D9SFP6 [Direct mapping] Tyrosine-protein kinase receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0038179 [neurotrophin signaling pathway] Show all	864 aa 97.1 kDa	Yes	1
NTRK3-201 ENSP00000347397 ENST00000355254	Q16288 [Direct mapping] NT-3 growth factor receptor X5DNW6 [Target identity:100%; Query identity:100%] Tyrosine-protein kinase receptor Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007507 [heart development] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030335 [positive regulation of cell migration] GO:0032148 [activation of protein kinase B activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0038179 [neurotrophin signaling pathway] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0050927 [positive regulation of positive chemotaxis] GO:0090630 [activation of GTPase activity] GO:2000251 [positive regulation of actin cytoskeleton reorganization] Show all	817 aa 91.8 kDa	Yes	1
NTRK3-202 ENSP00000350356 ENST00000357724	Q16288 [Direct mapping] NT-3 growth factor receptor Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007507 [heart development] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030335 [positive regulation of cell migration] GO:0032148 [activation of protein kinase B activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0038179 [neurotrophin signaling pathway] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0050927 [positive regulation of positive chemotaxis] GO:0090630 [activation of GTPase activity] GO:2000251 [positive regulation of actin cytoskeleton reorganization] Show all	831 aa 93.5 kDa	Yes	1
NTRK3-203 ENSP00000354207 ENST00000360948	Q16288 [Direct mapping] NT-3 growth factor receptor X5D2R1 [Target identity:100%; Query identity:100%] Tyrosine-protein kinase receptor Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001764 [neuron migration] GO:0001933 [negative regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005004 [GPI-linked ephrin receptor activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007507 [heart development] GO:0007623 [circadian rhythm] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0016020 [membrane] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019056 [modulation by virus of host transcription] GO:0030335 [positive regulation of cell migration] GO:0032148 [activation of protein kinase B activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0038179 [neurotrophin signaling pathway] GO:0042490 [mechanoreceptor differentiation] GO:0043065 [positive regulation of apoptotic process] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0045471 [response to ethanol] GO:0046777 [protein autophosphorylation] GO:0048013 [ephrin receptor signaling pathway] GO:0048665 [neuron fate specification] GO:0048678 [response to axon injury] GO:0048691 [positive regulation of axon extension involved in regeneration] GO:0048712 [negative regulation of astrocyte differentiation] GO:0050927 [positive regulation of positive chemotaxis] GO:0051412 [response to corticosterone] GO:0051965 [positive regulation of synapse assembly] GO:0060548 [negative regulation of cell death] GO:0070306 [lens fiber cell differentiation] GO:0071300 [cellular response to retinoic acid] GO:0090102 [cochlea development] GO:0090630 [activation of GTPase activity] GO:2000251 [positive regulation of actin cytoskeleton reorganization] Show all	839 aa 94.4 kDa	Yes	1
NTRK3-204 ENSP00000444673 ENST00000540489	Q16288 [Direct mapping] NT-3 growth factor receptor Q96CY4 [Target identity:100%; Query identity:100%] Neurotrophic tyrosine kinase, receptor, type 3; Neurotrophic tyrosine kinase, receptor, type 3, isoform CRA_e Show all	Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001933 [negative regulation of protein phosphorylation] GO:0001934 [positive regulation of protein phosphorylation] GO:0002039 [p53 binding] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005030 [neurotrophin receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005887 [integral component of plasma membrane] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007507 [heart development] GO:0008284 [positive regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0030335 [positive regulation of cell migration] GO:0032148 [activation of protein kinase B activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0038179 [neurotrophin signaling pathway] GO:0043121 [neurotrophin binding] GO:0043235 [receptor complex] GO:0050927 [positive regulation of positive chemotaxis] GO:0090630 [activation of GTPase activity] GO:2000251 [positive regulation of actin cytoskeleton reorganization] Show all	612 aa 68.5 kDa	Yes	1