Expression of ST8SIA2 in cancer - Summary

CANCER ATLAS

Gene description

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2

Protein class

Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Carcinoid

STAINING SUMMARY

HPA054518

GENE INFORMATION
Gene name	ST8SIA2 (HGNC Symbol)
Synonyms	HsT19690, SIAT8B, ST8SIA-II, STX
Description	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q26.1
Chromosome location (bp)	92393828 - 92468728
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140557 (version 83.38)
Entrez gene	8128
UniProt	Q92186 (UniProt - Evidence at transcript level)
neXtProt	NX_Q92186
Antibodypedia	ST8SIA2 antibodies

PROTEIN BROWSER

ST8SIA2-001	ST8SIA2-002	ST8SIA2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ST8SIA2-001 ENSP00000268164 ENST00000268164	Q92186 [Direct mapping] Alpha-2,8-sialyltransferase 8B B2R9U8 [Target identity:100%; Query identity:100%] Alpha-2,8-sialyltransferase 8B 1; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; cDNA, FLJ94563, Homo sapiens sialyltransferase 8B (alpha-2, 8-sialyltransferase)(SIAT8B), mRNA Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0000139 [Golgi membrane] GO:0001574 [ganglioside biosynthetic process] GO:0003828 [alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity] GO:0005769 [early endosome] GO:0005975 [carbohydrate metabolic process] GO:0006464 [cellular protein modification process] GO:0006486 [protein glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006491 [N-glycan processing] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0008373 [sialyltransferase activity] GO:0009311 [oligosaccharide metabolic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030173 [integral component of Golgi membrane] GO:0033691 [sialic acid binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0055037 [recycling endosome] GO:0097503 [sialylation] Show all	375 aa 42.4 kDa	Yes	0
ST8SIA2-002 ENSP00000437382 ENST00000539113	C6G488 [Direct mapping] Alpha-2,8-sialyltransferase 8B Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0006486 [protein glycosylation] GO:0008373 [sialyltransferase activity] GO:0030173 [integral component of Golgi membrane] GO:0097503 [sialylation] Show all	354 aa 40.2 kDa	Yes	0
ST8SIA2-003 ENSP00000450851 ENST00000555434	G3V2T1 [Direct mapping] Alpha-2,8-sialyltransferase 8B Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0006486 [protein glycosylation] GO:0008373 [sialyltransferase activity] GO:0030173 [integral component of Golgi membrane] GO:0097503 [sialylation] Show all	332 aa 37.7 kDa	Yes	0