Cell atlas - ST8SIA2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ST8SIA2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubule organizing center

Human cell
	Centrosome

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	ST8SIA2
Gene description	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubule organizing center.
RNA cell category	Cell line enhanced (AF22, RH-30, WM-115)
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubule organizing center (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA054518
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22, RH-30, WM-115) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubule organizing center.

Main location

Microtubule organizing center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA054518	RH-30	Microtubule organizing center
	HPA054518	U-2 OS	No staining
	HPA054518	U-251 MG	No staining

GENE INFORMATION
Gene name	ST8SIA2 (HGNC Symbol)
Synonyms	HsT19690, SIAT8B, ST8SIA-II, STX
Description	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q26.1
Chromosome location (bp)	92393828 - 92468728
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140557 (version 83.38)
Entrez gene	8128
UniProt	Q92186 (UniProt - Evidence at transcript level)
neXtProt	NX_Q92186
Antibodypedia	ST8SIA2 antibodies

PROTEIN BROWSER

ST8SIA2-001	ST8SIA2-002	ST8SIA2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ST8SIA2-001 ENSP00000268164 ENST00000268164	Q92186 [Direct mapping] Alpha-2,8-sialyltransferase 8B B2R9U8 [Target identity:100%; Query identity:100%] Alpha-2,8-sialyltransferase 8B 1; ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; cDNA, FLJ94563, Homo sapiens sialyltransferase 8B (alpha-2, 8-sialyltransferase)(SIAT8B), mRNA Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0000139 [Golgi membrane] GO:0001574 [ganglioside biosynthetic process] GO:0003828 [alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity] GO:0005769 [early endosome] GO:0005975 [carbohydrate metabolic process] GO:0006464 [cellular protein modification process] GO:0006486 [protein glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006491 [N-glycan processing] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0008373 [sialyltransferase activity] GO:0009311 [oligosaccharide metabolic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030173 [integral component of Golgi membrane] GO:0033691 [sialic acid binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0055037 [recycling endosome] GO:0097503 [sialylation] Show all	375 aa 42.4 kDa	Yes	0
ST8SIA2-002 ENSP00000437382 ENST00000539113	C6G488 [Direct mapping] Alpha-2,8-sialyltransferase 8B Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0006486 [protein glycosylation] GO:0008373 [sialyltransferase activity] GO:0030173 [integral component of Golgi membrane] GO:0097503 [sialylation] Show all	354 aa 40.2 kDa	Yes	0
ST8SIA2-003 ENSP00000450851 ENST00000555434	G3V2T1 [Direct mapping] Alpha-2,8-sialyltransferase 8B Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0006486 [protein glycosylation] GO:0008373 [sialyltransferase activity] GO:0030173 [integral component of Golgi membrane] GO:0097503 [sialylation] Show all	332 aa 37.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.