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MYLK3

CANCER ATLAS

Gene description

 Myosin light chain kinase 3

Protein class

 Enzymes, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040258

GENE INFORMATION

Gene name

 MYLK3 (HGNC Symbol)

Synonyms

 caMLCK, MLCK

Description

 Myosin light chain kinase 3 (HGNC Symbol)

Entrez gene summary

 Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]

Chromosome

 16

Cytoband

 q11.2

Chromosome location (bp)

 46703369 - 46790407

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140795 (version 83.38)

Entrez gene

 91807

UniProt

 Q32MK0 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q32MK0

Antibodypedia

 MYLK3 antibodies

PROTEIN BROWSER
MYLK3-001
MYLK3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYLK3-001
ENSP00000378288
ENST00000394809
Q32MK0 [Direct mapping]
Myosin light chain kinase 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002528 [regulation of vascular permeability involved in acute inflammatory response]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004687 [myosin light chain kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0015629 [actin cytoskeleton]
GO:0045214 [sarcomere organization]
GO:0048769 [sarcomerogenesis]
GO:0055003 [cardiac myofibril assembly]
GO:0060298 [positive regulation of sarcomere organization]
GO:0071347 [cellular response to interleukin-1]
Show all
 819 aa
88.4 kDa 		No 1
MYLK3-003
ENSP00000439297
ENST00000536476
Q32MK0 [Direct mapping]
Myosin light chain kinase 3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002528 [regulation of vascular permeability involved in acute inflammatory response]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004687 [myosin light chain kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0045214 [sarcomere organization]
GO:0048769 [sarcomerogenesis]
GO:0055003 [cardiac myofibril assembly]
GO:0060298 [positive regulation of sarcomere organization]
GO:0071347 [cellular response to interleukin-1]
Show all
 478 aa
52.7 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.