Tissue expression of MYLK3 - Summary - The Human Protein Atlas

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MYLK3

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MYLK3
Gene description	Myosin light chain kinase 3
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (heart muscle)
GTEx:	Tissue enriched (heart muscle)
FANTOM5:	Tissue enriched (heart muscle)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA040258
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (heart muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (heart muscle)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (heart muscle)

GENE INFORMATION
Gene name	MYLK3 (HGNC Symbol)
Synonyms	caMLCK, MLCK
Description	Myosin light chain kinase 3 (HGNC Symbol)
Entrez gene summary	Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]
Chromosome	16
Cytoband	q11.2
Chromosome location (bp)	46703369 - 46790407
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140795 (version 83.38)
Entrez gene	91807
UniProt	Q32MK0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q32MK0
Antibodypedia	MYLK3 antibodies

PROTEIN BROWSER

MYLK3-001	MYLK3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYLK3-001 ENSP00000378288 ENST00000394809	Q32MK0 [Direct mapping] Myosin light chain kinase 3 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002528 [regulation of vascular permeability involved in acute inflammatory response] GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0004687 [myosin light chain kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0015629 [actin cytoskeleton] GO:0045214 [sarcomere organization] GO:0048769 [sarcomerogenesis] GO:0055003 [cardiac myofibril assembly] GO:0060298 [positive regulation of sarcomere organization] GO:0071347 [cellular response to interleukin-1] Show all	819 aa 88.4 kDa	No	1
MYLK3-003 ENSP00000439297 ENST00000536476	Q32MK0 [Direct mapping] Myosin light chain kinase 3 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002528 [regulation of vascular permeability involved in acute inflammatory response] GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0004687 [myosin light chain kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0045214 [sarcomere organization] GO:0048769 [sarcomerogenesis] GO:0055003 [cardiac myofibril assembly] GO:0060298 [positive regulation of sarcomere organization] GO:0071347 [cellular response to interleukin-1] Show all	478 aa 52.7 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.