Expression of RHOT2 in cancer - Summary

CANCER ATLAS

Gene description

Ras homolog family member T2

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA012624	HPA012895

GENE INFORMATION
Gene name	RHOT2 (HGNC Symbol)
Synonyms	ARHT2, C16orf39, MIRO-2
Description	Ras homolog family member T2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	668086 - 674174
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140983 (version 83.38)
Entrez gene	89941
UniProt	Q8IXI1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IXI1
Antibodypedia	RHOT2 antibodies

PROTEIN BROWSER

RHOT2-001	RHOT2-014	RHOT2-021	RHOT2-024

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RHOT2-001 ENSP00000321971 ENST00000315082	Q8IXI1 [Direct mapping] Mitochondrial Rho GTPase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007005 [mitochondrion organization] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0008152 [metabolic process] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0019725 [cellular homeostasis] GO:0031307 [integral component of mitochondrial outer membrane] GO:0047497 [mitochondrion transport along microtubule] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0070062 [extracellular exosome] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	618 aa 68.1 kDa	No	1
RHOT2-014 ENSP00000456855 ENST00000561929	H3BST5 [Direct mapping] Mitochondrial Rho GTPase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0008152 [metabolic process] GO:0015031 [protein transport] GO:0016020 [membrane] Show all	208 aa 23.1 kDa	No	0
RHOT2-021 ENSP00000457437 ENST00000569197	H3BU27 [Direct mapping] Mitochondrial Rho GTPase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		155 aa 16.3 kDa	No	0
RHOT2-024 ENSP00000459564 ENST00000563134	I3L2C6 [Direct mapping] Mitochondrial Rho GTPase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0008152 [metabolic process] GO:0015031 [protein transport] GO:0016020 [membrane] Show all	214 aa 23.7 kDa	No	0