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RHOT2

GENERAL INFORMATION

Gene name

 RHOT2

Gene description

 Ras homolog family member T2

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA012624 , HPA012895
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RHOT2 (HGNC Symbol)

Synonyms

 ARHT2, C16orf39, MIRO-2

Description

 Ras homolog family member T2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 668086 - 674174

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140983 (version 83.38)

Entrez gene

 89941

UniProt

 Q8IXI1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IXI1

Antibodypedia

 RHOT2 antibodies

PROTEIN BROWSER
RHOT2-001
RHOT2-014
RHOT2-021
RHOT2-024

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RHOT2-001
ENSP00000321971
ENST00000315082
Q8IXI1 [Direct mapping]
Mitochondrial Rho GTPase 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007005 [mitochondrion organization]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008152 [metabolic process]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019725 [cellular homeostasis]
GO:0031307 [integral component of mitochondrial outer membrane]
GO:0047497 [mitochondrion transport along microtubule]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097345 [mitochondrial outer membrane permeabilization]
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 618 aa
68.1 kDa 		No 1
RHOT2-014
ENSP00000456855
ENST00000561929
H3BST5 [Direct mapping]
Mitochondrial Rho GTPase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008152 [metabolic process]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 208 aa
23.1 kDa 		No 0
RHOT2-021
ENSP00000457437
ENST00000569197
H3BU27 [Direct mapping]
Mitochondrial Rho GTPase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 155 aa
16.3 kDa 		No 0
RHOT2-024
ENSP00000459564
ENST00000563134
I3L2C6 [Direct mapping]
Mitochondrial Rho GTPase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008152 [metabolic process]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 214 aa
23.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.