Expression of RPRD1A in cancer - Summary

CANCER ATLAS

Gene description

Regulation of nuclear pre-mRNA domain containing 1A

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA040602

GENE INFORMATION
Gene name	RPRD1A (HGNC Symbol)
Synonyms	FLJ10656, HsT3101, P15RS
Description	Regulation of nuclear pre-mRNA domain containing 1A (HGNC Symbol)
Entrez gene summary	This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Dec 2014]
Chromosome	18
Cytoband	q12.2
Chromosome location (bp)	35984387 - 36067576
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141425 (version 83.38)
Entrez gene	55197
UniProt	Q96P16 (UniProt - Evidence at protein level)
neXtProt	NX_Q96P16
Antibodypedia	RPRD1A antibodies

PROTEIN BROWSER

RPRD1A-001	RPRD1A-002	RPRD1A-004	RPRD1A-005	RPRD1A-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPRD1A-001 ENSP00000381984 ENST00000399022	Q96P16 [Direct mapping] Regulation of nuclear pre-mRNA domain-containing protein 1A A0A024RC37 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016591 [DNA-directed RNA polymerase II, holoenzyme] GO:0070940 [dephosphorylation of RNA polymerase II C-terminal domain] Show all	312 aa 35.7 kDa	No	0
RPRD1A-002 ENSP00000465444 ENST00000588737	Q96P16 [Direct mapping] Regulation of nuclear pre-mRNA domain-containing protein 1A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016591 [DNA-directed RNA polymerase II, holoenzyme] GO:0070940 [dephosphorylation of RNA polymerase II C-terminal domain] Show all	276 aa 31.6 kDa	No	0
RPRD1A-004 ENSP00000349955 ENST00000357384	Q96P16 [Direct mapping] Regulation of nuclear pre-mRNA domain-containing protein 1A A0A024RC37 [Target identity:100%; Query identity:100%] Uncharacterized protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016591 [DNA-directed RNA polymerase II, holoenzyme] GO:0070940 [dephosphorylation of RNA polymerase II C-terminal domain] Show all	312 aa 35.7 kDa	No	0
RPRD1A-005 ENSP00000467991 ENST00000590898	Q96P16 [Direct mapping] Regulation of nuclear pre-mRNA domain-containing protein 1A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016591 [DNA-directed RNA polymerase II, holoenzyme] GO:0070940 [dephosphorylation of RNA polymerase II C-terminal domain] Show all	276 aa 31.6 kDa	No	0
RPRD1A-009 ENSP00000467268 ENST00000585953	K7EP82 [Direct mapping] Regulation of nuclear pre-mRNA domain-containing protein 1A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		123 aa 13.6 kDa	No	0