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Most of the malignant cells showed moderate to strong nuclear positivity. Many hepatocellular carcinomas, low grade non-Hodgkins lymphomas and renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
RPRD1A (HGNC Symbol)
Synonyms
FLJ10656, HsT3101, P15RS
Description
Regulation of nuclear pre-mRNA domain containing 1A (HGNC Symbol)
Entrez gene summary
This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Dec 2014]