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ESCO1

GENERAL INFORMATION

Gene name

 ESCO1

Gene description

 Establishment of sister chromatid cohesion N-acetyltransferase 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA042497
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ESCO1 (HGNC Symbol)

Synonyms

 EFO1, ESO1, KIAA1911

Description

 Establishment of sister chromatid cohesion N-acetyltransferase 1 (HGNC Symbol)

Entrez gene summary

 ESCO1 belongs to a conserved family of acetyltransferases involved in sister chromatid cohesion (Hou and Zou, 2005 [PubMed 15958495]).[supplied by OMIM, Mar 2008]

Chromosome

 18

Cytoband

 q11.2

Chromosome location (bp)

 21529281 - 21600884

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141446 (version 83.38)

Entrez gene

 114799

UniProt

 Q5FWF5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5FWF5

Antibodypedia

 ESCO1 antibodies

PROTEIN BROWSER
ESCO1-001
ESCO1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ESCO1-001
ENSP00000269214
ENST00000269214
Q5FWF5 [Direct mapping]
N-acetyltransferase ESCO1
A0A024RC19 [Target identity:100%; Query identity:100%]
Establishment of cohesion 1 homolog 1 (S. cerevisiae), isoform CRA_b
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000278 [mitotic cell cycle]
GO:0000785 [chromatin]
GO:0005654 [nucleoplasm]
GO:0006275 [regulation of DNA replication]
GO:0007062 [sister chromatid cohesion]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0034421 [post-translational protein acetylation]
GO:0046872 [metal ion binding]
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 840 aa
95 kDa 		No 0
ESCO1-201
ENSP00000484873
ENST00000622333
A0A0C4DH04 [Direct mapping]
N-acetyltransferase ESCO1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0006275 [regulation of DNA replication]
GO:0007062 [sister chromatid cohesion]
GO:0034421 [post-translational protein acetylation]
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 172 aa
19.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.