Tissue expression of SLC13A5 - Summary - The Human Protein Atlas

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SLC13A5

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SLC13A5
Gene description	Solute carrier family 13 (sodium-dependent citrate transporter), member 5
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (liver)
GTEx:	Tissue enriched (liver)
FANTOM5:	Group enriched (liver, salivary gland)

Protein evidence

Evidence at protein level

Protein expression

Membranous expression in liver.

DATA RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA044343
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (liver, salivary gland)

GENE INFORMATION
Gene name	SLC13A5 (HGNC Symbol)
Synonyms	NACT
Description	Solute carrier family 13 (sodium-dependent citrate transporter), member 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein belonging to the solute carrier family 13 group of proteins. This family member is a sodium-dependent citrate cotransporter that may regulate metabolic processes. Mutations in this gene cause early infantile epileptic encephalopathy 25. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	6684713 - 6713567
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141485 (version 83.38)
Entrez gene	284111
UniProt	Q86YT5 (UniProt - Evidence at protein level)
neXtProt	NX_Q86YT5
Antibodypedia	SLC13A5 antibodies

PROTEIN BROWSER

SLC13A5-001	SLC13A5-002	SLC13A5-003	SLC13A5-004	SLC13A5-012	SLC13A5-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC13A5-001 ENSP00000406220 ENST00000433363	Q86YT5 [Direct mapping] Solute carrier family 13 member 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006814 [sodium ion transport] GO:0006842 [tricarboxylic acid transport] GO:0015137 [citrate transmembrane transporter activity] GO:0015141 [succinate transmembrane transporter activity] GO:0015142 [tricarboxylic acid transmembrane transporter activity] GO:0015744 [succinate transport] GO:0015746 [citrate transport] GO:0016020 [membrane] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0035674 [tricarboxylic acid transmembrane transport] GO:0055085 [transmembrane transport] GO:0071422 [succinate transmembrane transport] Show all	568 aa 63.1 kDa	No	>9
SLC13A5-002 ENSP00000459372 ENST00000573648	Q86YT5 [Direct mapping] Solute carrier family 13 member 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006814 [sodium ion transport] GO:0015137 [citrate transmembrane transporter activity] GO:0015141 [succinate transmembrane transporter activity] GO:0015746 [citrate transport] GO:0016020 [membrane] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0035674 [tricarboxylic acid transmembrane transport] GO:0055085 [transmembrane transport] GO:0071422 [succinate transmembrane transport] Show all	522 aa 58.1 kDa	No	>9
SLC13A5-003 ENSP00000370464 ENST00000381074	Q86YT5 [Direct mapping] Solute carrier family 13 member 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006814 [sodium ion transport] GO:0015137 [citrate transmembrane transporter activity] GO:0015141 [succinate transmembrane transporter activity] GO:0015746 [citrate transport] GO:0016020 [membrane] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0035674 [tricarboxylic acid transmembrane transport] GO:0055085 [transmembrane transport] GO:0071422 [succinate transmembrane transport] Show all	525 aa 58.1 kDa	No	>9
SLC13A5-004 ENSP00000293800 ENST00000293800	Q86YT5 [Direct mapping] Solute carrier family 13 member 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006814 [sodium ion transport] GO:0015137 [citrate transmembrane transporter activity] GO:0015141 [succinate transmembrane transporter activity] GO:0015746 [citrate transport] GO:0016020 [membrane] GO:0017153 [sodium:dicarboxylate symporter activity] GO:0035674 [tricarboxylic acid transmembrane transport] GO:0055085 [transmembrane transport] GO:0071422 [succinate transmembrane transport] Show all	551 aa 61.2 kDa	No	>9
SLC13A5-012 ENSP00000460037 ENST00000570687	I3L2Y7 [Direct mapping] Solute carrier family 13 member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	94 aa 9.9 kDa	Yes	1
SLC13A5-013 ENSP00000461622 ENST00000572352	I3L4X6 [Direct mapping] Solute carrier family 13 member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	167 aa 18.4 kDa	No	2

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The Human Protein Atlas

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