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PIK3R5

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GENERAL INFORMATION

Gene name

 PIK3R5

Gene description

 Phosphoinositide-3-kinase, regulatory subunit 5

Protein class

 Disease related genes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the microtubule organizing center.

RNA cell category

 Cell line enhanced (HDLM-2, U-937)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

Additional location

 In addition localized to the Microtubule organizing center (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA044505 , HPA052412
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, U-937)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the microtubule organizing center.

Main location

 Cytosol (supported)

Additional location

 Microtubule organizing center (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA044505 REH Microtubule organizing center
Cytosol Intensity
HPA044505 U-2 OS Cytosol
HPA052412 REH Cytosol
HPA052412 U-2 OS Microtubule organizing center
Cytosol

GENE INFORMATION

Gene name

 PIK3R5 (HGNC Symbol)

Synonyms

 p101, P101-PI3K

Description

 Phosphoinositide-3-kinase, regulatory subunit 5 (HGNC Symbol)

Entrez gene summary

 Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 8878911 - 8965712

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141506 (version 83.38)

Entrez gene

 23533

UniProt

 Q8WYR1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WYR1

Antibodypedia

 PIK3R5 antibodies

PROTEIN BROWSER
PIK3R5-001
PIK3R5-004
PIK3R5-014
PIK3R5-015
PIK3R5-201
PIK3R5-202
PIK3R5-203
PIK3R5-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PIK3R5-001
ENSP00000462433
ENST00000581552
Q8WYR1 [Direct mapping]
Phosphoinositide 3-kinase regulatory subunit 5
L7RT34 [Target identity:100%; Query identity:100%]
Phosphoinositide-3-kinase, regulatory subunit 5
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005944 [phosphatidylinositol 3-kinase complex, class IB]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
GO:0051897 [positive regulation of protein kinase B signaling]
Show all
 880 aa
97.3 kDa 		No 0
PIK3R5-004
ENSP00000462680
ENST00000584803
J3KSW1 [Direct mapping]
Phosphoinositide 3-kinase regulatory subunit 5
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005944 [phosphatidylinositol 3-kinase complex, class IB]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
Show all
 879 aa
97.2 kDa 		No 0
PIK3R5-014
ENSP00000462824
ENST00000585260
J3KT66 [Direct mapping]
Phosphoinositide 3-kinase regulatory subunit 5
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005944 [phosphatidylinositol 3-kinase complex, class IB]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
Show all
 93 aa
10.5 kDa 		No 0
PIK3R5-015
ENSP00000461966
ENST00000581895
J3KRE9 [Direct mapping]
Phosphoinositide 3-kinase regulatory subunit 5
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005944 [phosphatidylinositol 3-kinase complex, class IB]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
Show all
 44 aa
4.9 kDa 		No 0
PIK3R5-201
ENSP00000392812
ENST00000447110
Q8WYR1 [Direct mapping]
Phosphoinositide 3-kinase regulatory subunit 5
L7RT34 [Target identity:100%; Query identity:100%]
Phosphoinositide-3-kinase, regulatory subunit 5
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0005944 [phosphatidylinositol 3-kinase complex, class IB]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043551 [regulation of phosphatidylinositol 3-kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
GO:0051897 [positive regulation of protein kinase B signaling]
Show all
 880 aa
97.3 kDa 		No 0
PIK3R5-202
ENSP00000477795
ENST00000611902
Q8WYR1 [Direct mapping]
Phosphoinositide 3-kinase regulatory subunit 5
Show all
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005944 [phosphatidylinositol 3-kinase complex, class IB]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
GO:0051897 [positive regulation of protein kinase B signaling]
Show all
 494 aa
54.9 kDa 		No 0
PIK3R5-203
ENSP00000484211
ENST00000616147
Q8WYR1 [Direct mapping]
Phosphoinositide 3-kinase regulatory subunit 5
Show all
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005944 [phosphatidylinositol 3-kinase complex, class IB]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
GO:0051897 [positive regulation of protein kinase B signaling]
Show all
 494 aa
54.9 kDa 		No 0
PIK3R5-204
ENSP00000485280
ENST00000623421
Q8WYR1 [Direct mapping]
Phosphoinositide 3-kinase regulatory subunit 5
Show all
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005944 [phosphatidylinositol 3-kinase complex, class IB]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0030168 [platelet activation]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046935 [1-phosphatidylinositol-3-kinase regulator activity]
GO:0051897 [positive regulation of protein kinase B signaling]
Show all
 494 aa
54.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.