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Strong nuclear staining was observed in several cases of malignant gliomas, colorectal, ovarian, urothelial, gastric and pancreatic cancers. A few cases of squamous cell carcinomas, malignant melanoma, testicular and breast cancers showed moderate to strong nuclear positivity. Remaining malignant cells showed moderate nuclear immunoreactivity in a fraction of cells or were negative.
Several cases of basal cell carcinoma in skin, colorectal and ovarian cancers showed strong nuclear staining. Several testicular cancers as well as cases of lung and pancreastic cancers exhibited moderate positivity. Remaining malignant cells were in general weakly stained or negative.
Moderate to strong nuclear staining in several cases of most cancer types. Lymphomas, breast, prostate, endometrial and renal carcinomas were negative.
GENE INFORMATION
Gene name
TP53 (HGNC Symbol)
Synonyms
LFS1, p53
Description
Tumor protein p53 (HGNC Symbol)
Entrez gene summary
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]