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TP53

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GENERAL INFORMATION

Gene name

 TP53

Gene description

 Tumor protein p53

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Transcription factors
Transporters

Predicted localization

 Intracellular

Number of transcripts

 25
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

siRNA

 The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB039238 , HPA051244
SHOW MORE

ASSAYS
RNA expression
Human cells
siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB039238 A-431 Nucleoplasm Intensity
CAB039238 U-2 OS Nucleoplasm Intensity
CAB039238 U-251 MG Nucleoplasm Intensity
HPA051244 A-431 Nucleoplasm Intensity
HPA051244 U-251 MG Nucleoplasm Intensity

siRNA VALIDATION
 

Relative fluorescence intensity (RFI)

Antibody

 HPA051244

siRNA validation

 Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

 Nuclear region of segmented cells in 10x-images

siRNA 2

RFI

 73%

p-value

 < 0.01
 

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail 10x

Thumbnail 40x

Antibody

Sample

Cell line
HPA051244 siRNA 2 U-2 OS
HPA051244 scrambled U-2 OS

GENE INFORMATION

Gene name

 TP53 (HGNC Symbol)

Synonyms

 LFS1, p53

Description

 Tumor protein p53 (HGNC Symbol)

Entrez gene summary

 This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 7661779 - 7687550

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141510 (version 83.38)

Entrez gene

 7157

UniProt

 P04637 (UniProt - Evidence at protein level)

neXtProt

 NX_P04637

Antibodypedia

 TP53 antibodies

PROTEIN BROWSER
«
TP53-001
TP53-002
TP53-003
TP53-004
TP53-005
TP53-006
TP53-007
TP53-008
TP53-013
TP53-014
TP53-015
TP53-017
TP53-018
TP53-019
TP53-020
TP53-021
TP53-022
TP53-023
TP53-024
TP53-025
TP53-026
TP53-027
TP53-028
TP53-201
TP53-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TP53-001
ENSP00000269305
ENST00000269305
P04637 [Direct mapping]
Cellular tumor antigen p53
K7PPA8 [Target identity:100%; Query identity:100%]
Cellular tumor antigen p53
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000790 [nuclear chromatin]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001701 [in utero embryonic development]
GO:0001756 [somitogenesis]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0002309 [T cell proliferation involved in immune response]
GO:0002326 [B cell lineage commitment]
GO:0002360 [T cell lineage commitment]
GO:0002931 [response to ischemia]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006979 [response to oxidative stress]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007369 [gastrulation]
GO:0007406 [negative regulation of neuroblast proliferation]
GO:0007417 [central nervous system development]
GO:0007507 [heart development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008156 [negative regulation of DNA replication]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0009303 [rRNA transcription]
GO:0009411 [response to UV]
GO:0009651 [response to salt stress]
GO:0009792 [embryo development ending in birth or egg hatching]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010666 [positive regulation of cardiac muscle cell apoptotic process]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0021549 [cerebellum development]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031052 [chromosome breakage]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0033077 [T cell differentiation in thymus]
GO:0034103 [regulation of tissue remodeling]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035033 [histone deacetylase regulator activity]
GO:0035035 [histone acetyltransferase binding]
GO:0035264 [multicellular organism growth]
GO:0035690 [cellular response to drug]
GO:0035794 [positive regulation of mitochondrial membrane permeability]
GO:0035861 [site of double-strand break]
GO:0042127 [regulation of cell proliferation]
GO:0042149 [cellular response to glucose starvation]
GO:0042493 [response to drug]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043234 [protein complex]
GO:0043504 [mitochondrial DNA repair]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043621 [protein self-association]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045861 [negative regulation of proteolysis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048512 [circadian behavior]
GO:0048568 [embryonic organ development]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051276 [chromosome organization]
GO:0051402 [neuron apoptotic process]
GO:0051721 [protein phosphatase 2A binding]
GO:0051726 [regulation of cell cycle]
GO:0060411 [cardiac septum morphogenesis]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0070243 [regulation of thymocyte apoptotic process]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0070266 [necroptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0071494 [cellular response to UV-C]
GO:0071850 [mitotic cell cycle arrest]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0072363 [regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901525 [negative regulation of macromitophagy]
GO:1902108 [regulation of mitochondrial membrane permeability involved in apoptotic process]
GO:1902253 [regulation of intrinsic apoptotic signaling pathway by p53 class mediator]
GO:1904024 [negative regulation of glucose catabolic process to lactate via pyruvate]
GO:1990144 [intrinsic apoptotic signaling pathway in response to hypoxia]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:2000269 [regulation of fibroblast apoptotic process]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2000772 [regulation of cellular senescence]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 393 aa
43.7 kDa 		No 0
TP53-002
ENSP00000391478
ENST00000445888
P04637 [Direct mapping]
Cellular tumor antigen p53
K7PPA8 [Target identity:100%; Query identity:100%]
Cellular tumor antigen p53
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000790 [nuclear chromatin]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0035690 [cellular response to drug]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043234 [protein complex]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043621 [protein self-association]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048512 [circadian behavior]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 393 aa
43.7 kDa 		No 0
TP53-003
ENSP00000426252
ENST00000503591
E9PCY9 [Direct mapping]
Cellular tumor antigen p53
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005657 [replication fork]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0010165 [response to X-ray]
GO:0031065 [positive regulation of histone deacetylation]
GO:0034644 [cellular response to UV]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
Show all
 128 aa
13.7 kDa 		No 0
TP53-004
ENSP00000398846
ENST00000455263
P04637 [Direct mapping]
Cellular tumor antigen p53
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000790 [nuclear chromatin]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0035690 [cellular response to drug]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043234 [protein complex]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043621 [protein self-association]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048512 [circadian behavior]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 346 aa
38.5 kDa 		No 0
TP53-005
ENSP00000391127
ENST00000420246
P04637 [Direct mapping]
Cellular tumor antigen p53
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000790 [nuclear chromatin]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0035690 [cellular response to drug]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043234 [protein complex]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043621 [protein self-association]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048512 [circadian behavior]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 341 aa
37.8 kDa 		No 0
TP53-006
ENSP00000484409
ENST00000504290
P04637 [Direct mapping]
Cellular tumor antigen p53
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000790 [nuclear chromatin]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0035690 [cellular response to drug]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043234 [protein complex]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043621 [protein self-association]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048512 [circadian behavior]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 214 aa
24.4 kDa 		No 0
TP53-007
ENSP00000478499
ENST00000510385
P04637 [Direct mapping]
Cellular tumor antigen p53
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000790 [nuclear chromatin]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0035690 [cellular response to drug]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043234 [protein complex]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043621 [protein self-association]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048512 [circadian behavior]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 209 aa
23.7 kDa 		No 0
TP53-008
ENSP00000481179
ENST00000504937
P04637 [Direct mapping]
Cellular tumor antigen p53
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000790 [nuclear chromatin]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0035690 [cellular response to drug]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043234 [protein complex]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043621 [protein self-association]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048512 [circadian behavior]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 261 aa
29.6 kDa 		No 0
TP53-013
ENSP00000423862
ENST00000514944
E9PFT5 [Direct mapping]
Cellular tumor antigen p53
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0010165 [response to X-ray]
GO:0031065 [positive regulation of histone deacetylation]
GO:0034644 [cellular response to UV]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046872 [metal ion binding]
Show all
 155 aa
17.7 kDa 		No 0
TP53-014
ENSP00000424104
ENST00000508793
E7EMR6 [Direct mapping]
Cellular tumor antigen p53
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0010165 [response to X-ray]
GO:0031065 [positive regulation of histone deacetylation]
GO:0034644 [cellular response to UV]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046872 [metal ion binding]
Show all
 165 aa
17.8 kDa 		No 0
TP53-015
ENSP00000425104
ENST00000509690
E7ESS1 [Direct mapping]
Cellular tumor antigen p53
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0010165 [response to X-ray]
GO:0031065 [positive regulation of histone deacetylation]
GO:0034644 [cellular response to UV]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046872 [metal ion binding]
Show all
 199 aa
22.5 kDa 		No 0
TP53-017
ENSP00000458393
ENST00000576024
I3L0W9 [Direct mapping]
Cellular tumor antigen p53
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0005657 [replication fork]
GO:0010165 [response to X-ray]
GO:0031065 [positive regulation of histone deacetylation]
GO:0034644 [cellular response to UV]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
Show all
 31 aa
3.4 kDa 		No 0
TP53-018
ENSP00000410739
ENST00000413465
E7EQX7 [Direct mapping]
Cellular tumor antigen p53
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0010165 [response to X-ray]
GO:0031065 [positive regulation of histone deacetylation]
GO:0034644 [cellular response to UV]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046872 [metal ion binding]
Show all
 285 aa
31.5 kDa 		No 0
TP53-019
ENSP00000352610
ENST00000359597
J3KP33 [Direct mapping]
Cellular tumor antigen p53
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0010165 [response to X-ray]
GO:0031065 [positive regulation of histone deacetylation]
GO:0034644 [cellular response to UV]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046872 [metal ion binding]
Show all
 343 aa
37.9 kDa 		No 0
TP53-020
ENSP00000473895
ENST00000604348
S4R334 [Direct mapping]
Cellular tumor antigen p53
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005657 [replication fork]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0010165 [response to X-ray]
GO:0031065 [positive regulation of histone deacetylation]
GO:0034644 [cellular response to UV]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
Show all
 143 aa
15.4 kDa 		No 0
TP53-021
ENSP00000481638
ENST00000620739
P04637 [Direct mapping]
Cellular tumor antigen p53
H2EHT1 [Target identity:100%; Query identity:100%]
Cellular tumor antigen p53
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000790 [nuclear chromatin]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0035690 [cellular response to drug]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043234 [protein complex]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043621 [protein self-association]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048512 [circadian behavior]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 354 aa
39.3 kDa 		No 0
TP53-022
ENSP00000478219
ENST00000610292
P04637 [Direct mapping]
Cellular tumor antigen p53
H2EHT1 [Target identity:100%; Query identity:100%]
Cellular tumor antigen p53
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000790 [nuclear chromatin]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0035690 [cellular response to drug]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043234 [protein complex]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043621 [protein self-association]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048512 [circadian behavior]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 354 aa
39.3 kDa 		No 0
TP53-023
ENSP00000484375
ENST00000619186
A0A087X1Q1 [Direct mapping]
Cellular tumor antigen p53
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0010165 [response to X-ray]
GO:0031065 [positive regulation of histone deacetylation]
GO:0034644 [cellular response to UV]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046872 [metal ion binding]
GO:0051262 [protein tetramerization]
Show all
 234 aa
26.6 kDa 		No 0
TP53-024
ENSP00000481401
ENST00000618944
A0A087WXZ1 [Direct mapping]
Cellular tumor antigen p53
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0010165 [response to X-ray]
GO:0031065 [positive regulation of histone deacetylation]
GO:0034644 [cellular response to UV]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046872 [metal ion binding]
Show all
 182 aa
20.7 kDa 		No 0
TP53-025
ENSP00000482222
ENST00000622645
P04637 [Direct mapping]
Cellular tumor antigen p53
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000790 [nuclear chromatin]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0035690 [cellular response to drug]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043234 [protein complex]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043621 [protein self-association]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048512 [circadian behavior]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 302 aa
33.5 kDa 		No 0
TP53-026
ENSP00000477531
ENST00000610623
A0A087WT22 [Direct mapping]
Cellular tumor antigen p53
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0010165 [response to X-ray]
GO:0031065 [positive regulation of histone deacetylation]
GO:0034644 [cellular response to UV]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046872 [metal ion binding]
Show all
 187 aa
21.4 kDa 		No 0
TP53-027
ENSP00000480868
ENST00000610538
P04637 [Direct mapping]
Cellular tumor antigen p53
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000790 [nuclear chromatin]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0035690 [cellular response to drug]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043234 [protein complex]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043621 [protein self-association]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048512 [circadian behavior]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 307 aa
34.2 kDa 		No 0
TP53-028
ENSP00000482537
ENST00000619485
P04637 [Direct mapping]
Cellular tumor antigen p53
H2EHT1 [Target identity:100%; Query identity:100%]
Cellular tumor antigen p53
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000790 [nuclear chromatin]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0035690 [cellular response to drug]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043234 [protein complex]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043621 [protein self-association]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048512 [circadian behavior]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 354 aa
39.3 kDa 		No 0
TP53-201
ENSP00000482903
ENST00000615910
A0A087WZU8 [Direct mapping]
Cellular tumor antigen p53
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0010165 [response to X-ray]
GO:0031065 [positive regulation of histone deacetylation]
GO:0034644 [cellular response to UV]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046872 [metal ion binding]
GO:0051262 [protein tetramerization]
Show all
 382 aa
42.6 kDa 		No 0
TP53-202
ENSP00000482258
ENST00000617185
P04637 [Direct mapping]
Cellular tumor antigen p53
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000790 [nuclear chromatin]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0035690 [cellular response to drug]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043234 [protein complex]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043621 [protein self-association]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048512 [circadian behavior]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900119 [positive regulation of execution phase of apoptosis]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 341 aa
37.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.