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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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CBX4
  • TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CBX4

Gene description

Chromobox homolog 4

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (bone marrow)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General nuclear and cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA008228
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
N/A
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

CBX4 (HGNC Symbol)

Synonyms

hPC2, NBP16, PC2

Description

Chromobox homolog 4 (HGNC Symbol)

Entrez gene summary

Chromosome

17

Cytoband

q25.3

Chromosome location (bp)

79833156 - 79839429

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000141582 (version 83.38)

Entrez gene

8535

UniProt

O00257 (UniProt - Evidence at protein level)

neXtProt

NX_O00257

Antibodypedia

CBX4 antibodies

PROTEIN BROWSER

CBX4-001
CBX4-002
CBX4-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CBX4-001
ENSP00000269397
ENST00000269397
O00257 [Direct mapping]
E3 SUMO-protein ligase CBX4
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003682 [chromatin binding]
GO:0003714 [transcription corepressor activity]
GO:0003727 [single-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0016568 [chromatin modification]
GO:0016604 [nuclear body]
GO:0016607 [nuclear speck]
GO:0016874 [ligase activity]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0019899 [enzyme binding]
GO:0031519 [PcG protein complex]
GO:0032183 [SUMO binding]
GO:0035064 [methylated histone binding]
GO:0035102 [PRC1 complex]
GO:0043066 [negative regulation of apoptotic process]
GO:0043687 [post-translational protein modification]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044267 [cellular protein metabolic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051219 [phosphoprotein binding]
Show all
560 aa
61.4 kDa
No 0
CBX4-002
ENSP00000415348
ENST00000448310
F8WCW6 [Direct mapping]
E3 SUMO-protein ligase CBX4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
Show all
60 aa
7.2 kDa
No 0
CBX4-004
ENSP00000461198
ENST00000495122
I3L4F1 [Direct mapping]
E3 SUMO-protein ligase CBX4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
90 aa
10.2 kDa
No 0

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The Human Protein Atlas project is funded
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