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Several melanomas, carcinoids and thyroid cancers along with a few pancreatic cancers exhibited moderate to strong cytoplasmic positivity. A few cases of colorectal, prostate, ovarian, gastric and liver cancers showed weak to moderate staining. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
PMAIP1 (HGNC Symbol)
Synonyms
APR, NOXA
Description
Phorbol-12-myristate-13-acetate-induced protein 1 (HGNC Symbol)
Q13794 [Direct mapping] Phorbol-12-myristate-13-acetate-induced protein 1
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Predicted intracellular proteins
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GO:0001836 [release of cytochrome c from mitochondria] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0009411 [response to UV] GO:0010165 [response to X-ray] GO:0010498 [proteasomal protein catabolic process] GO:0010907 [positive regulation of glucose metabolic process] GO:0010917 [negative regulation of mitochondrial membrane potential] GO:0012501 [programmed cell death] GO:0032461 [positive regulation of protein oligomerization] GO:0042149 [cellular response to glucose starvation] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043029 [T cell homeostasis] GO:0043065 [positive regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043331 [response to dsRNA] GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator] GO:0043525 [positive regulation of neuron apoptotic process] GO:0046902 [regulation of mitochondrial membrane permeability] GO:0048147 [negative regulation of fibroblast proliferation] GO:0051607 [defense response to virus] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0071456 [cellular response to hypoxia] GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator] GO:0072593 [reactive oxygen species metabolic process] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0097193 [intrinsic apoptotic signaling pathway] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1902043 [positive regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]